Kaposi's sarcoma after alpha-interferon treatment for HIV-negative T-cell lymphoma

S. Ariad, D. Lewis, W. R. Bezwoda

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

A 54-year-old HIV-negative patient suffering from T-cell lymphoma of Lennert's lymphoma (Lel) type was treated for 13 months with interferon α2b. While on treatment with interferon the patient demonstrated suppression of total and CD4+ lymphocytes to levels <0,5 and 0,2 x 109/l, respectively. Although interferon was successful in controlling the lymphoma the clinical course was complicated by the rapid development of aggressive, fatal Kaposi's sarcoma shortly after cessation of interferon treatment. It is suggested that the immunosuppressive effect of interferon therapy (or the T-cell lymphoma or both) may have played a role in the development of Kaposi's sarcoma as a second malignancy.

Original languageEnglish
Pages (from-to)430-431
Number of pages2
JournalSouth African Medical Journal
Volume83
Issue number6
StatePublished - 26 Jul 1993
Externally publishedYes

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