Key feature of the catalytic cycle of TNF-α converting enzyme involves communication between distal protein sites and the enzyme catalytic core

Keyphrases

• Catalytic Cycle 100%
• Enzyme Catalysis 100%
• Catalytic Core 100%
• Converting Enzyme 100%
• Charge Transition 100%
• Substrate Turnover 66%
• Reaction Model 66%
• Network Routing 33%
• Metal Ions 33%
• Protease 33%
• Spectroscopic Techniques 33%
• Membrane Binding 33%
• Structural Chemistry 33%
• Proteolysis 33%
• Pathological Process 33%
• Zinc Ion 33%
• Substrate Recognition 33%
• Signal Transduction Pathway 33%
• Extracellular Domain 33%
• Stopped Flow 33%
• Drug Design 33%
• Zinc-dependent 33%
• Substrate Binding 33%
• Multiple Signals 33%
• Reaction Kinetics 33%
• Metalloproteinases 33%
• Peptide Substrate 33%
• Zinc Metalloprotease 33%
• Physiological Substrates 33%
• Catalytic Zinc 33%
• Product Release 33%
• Local Charge 33%
• Reaction Intermediates 33%
• Transient Kinetic Analysis 33%
• Transient Metal 33%
• Metal Coordination Chemistry 33%
• Metal Proteins 33%
• Protein Reaction 33%
• Catalytic Metal Ions 33%
• Lifetime of Transient 33%
• Tumor Necrosis Factor-α Converting Enzyme 33%
• Dynamic Charge 33%
• Metal Products 33%
• Metal Ion Release 33%
• Peptide Hydrolysis 33%

Biochemistry, Genetics and Molecular Biology

• Enzyme 100%
• Tumor Necrosis Factor 100%
• Enzymatic Hydrolysis 50%
• Metalloproteinase 50%
• Metalloendopeptidase 50%
• Kinetics 50%
• Lifespan 25%
• Signal Transduction 25%
• Protein Catabolism 25%
• Protease 25%
• Zinc Ion 25%
• Chemical Reaction Kinetics 25%