TY - JOUR
T1 - Kidney function and other factors and their association with falls
AU - SCOPE investigators
AU - Britting, Sabine
AU - Artzi-Medvedik, Rada
AU - Fabbietti, Paolo
AU - Tap, Lisanne
AU - Mattace-Raso, Francesco
AU - Corsonello, Andrea
AU - Lattanzio, Fabrizia
AU - Ärnlöv, Johan
AU - Carlsson, Axel C.
AU - Roller-Wirnsberger, Regina
AU - Wirnsberger, Gerhard
AU - Kostka, Tomasz
AU - Guligowska, Agnieszka
AU - Formiga, Francesc
AU - Moreno-Gonzalez, Rafael
AU - Gil, Pedro
AU - Martinez, Sara Lainez
AU - Kob, Robert
AU - Melzer, Itshak
AU - Freiberger, Ellen
AU - Lattanzio, Fabrizia
AU - Corsonello, A.
AU - Bustacchini, Silvia
AU - Bolognini, Silvia
AU - D'Ascoli, Paola
AU - Moresi, Raffaella
AU - Di Stefano, Giuseppina
AU - Giammarchi, Cinzia
AU - Bonfigli, Anna Rita
AU - Galeazzi, Roberta
AU - Lenci, Federica
AU - Bella, Stefano Della
AU - Bordoni, Enrico
AU - Provinciali, Mauro
AU - Giacconi, Robertina
AU - Giuli, Cinzia
AU - Postacchini, Demetrio
AU - Garasto, Sabrina
AU - Cozza, Annalisa
AU - Guarasci, Francesco
AU - D'Alia, Sonia
AU - Firmani, Romano
AU - Nacciariti, Moreno
AU - Di Rosa, Mirko
AU - Fabbietti, Paolo
N1 - Publisher Copyright:
© 2020 The Author(s).
PY - 2020/10/2
Y1 - 2020/10/2
N2 - Background: Reduced kidney function has become a major public health concern, especially among older people, as Chronic Kidney Disease (CKD) is associated with increased risk of end stage renal disease and mortality. Falls are a serious negative health outcome in older persons with one third of people aged 65 years experiencing a fall per year and increasing fall rates with increasing age. The impact of CKD on falls in older community-dwelling persons is not well investigated. Additionally, lower urinary tract symptoms (LUTS) may also increase the risk of falls. Therefore, our aim was to investigate the impact of CKD and LUTS on falls as well as on injurious falls. Methods: The SCOPE study is an observational, multinational, multicenter, prospective cohort study involving community-dwelling older persons aged 75 years and more recruited from August 2016 to March 2018 in seven European countries. The main outcomes of the present study were any falls and any injurious falls during the 12 months before enrolment. The cross-sectional association of estimated glomerular filtration rate (eGFR) and LUTS with study outcomes was investigated by logistic regression analysis adjusted for baseline characteristics of enrolled subjects. Results: Our series consisted of 2256 SCOPE participants (median age = 79.5 years, 55.7% female). Of them, 746 participants experienced a fall and 484 reported an injurious fall in the 12 months prior to baseline assessment. CKD was not significantly associated with falls (OR = 0.95, 95%CI = 0.79-1.14 for eGFR< 60; OR = 1.02, 95%CI = 0.81-1.28 for eGFR< 45; OR = 1.08, 95%CI = 0.74-1.57 for eGFR< 30) or injurious falls (OR = 0.91, 95%CI = 0.67-1.24 for eGFR< 60; OR = 0.93, 95%CI = 0.63-1.37 for eGFR< 45; OR = 1.19, 95%CI = 0.62-2.29 for eGFR< 30). LUTS were found significantly associated with both falls (OR = 1.56, 95%CI = 1.29-1.89) and injurious falls (OR = 1.58, 95%CI = 1.14-2.19), and such associations were confirmed in all multivariable models. Conclusions: Cross-sectional data suggest that CKD may not be associated with history of falls or injurious falls, whereas LUTS is significantly associated with the outcomes. Trial registration: This study was registered on 25th February 2016 at clinicaltrials.gov (NCT02691546).
AB - Background: Reduced kidney function has become a major public health concern, especially among older people, as Chronic Kidney Disease (CKD) is associated with increased risk of end stage renal disease and mortality. Falls are a serious negative health outcome in older persons with one third of people aged 65 years experiencing a fall per year and increasing fall rates with increasing age. The impact of CKD on falls in older community-dwelling persons is not well investigated. Additionally, lower urinary tract symptoms (LUTS) may also increase the risk of falls. Therefore, our aim was to investigate the impact of CKD and LUTS on falls as well as on injurious falls. Methods: The SCOPE study is an observational, multinational, multicenter, prospective cohort study involving community-dwelling older persons aged 75 years and more recruited from August 2016 to March 2018 in seven European countries. The main outcomes of the present study were any falls and any injurious falls during the 12 months before enrolment. The cross-sectional association of estimated glomerular filtration rate (eGFR) and LUTS with study outcomes was investigated by logistic regression analysis adjusted for baseline characteristics of enrolled subjects. Results: Our series consisted of 2256 SCOPE participants (median age = 79.5 years, 55.7% female). Of them, 746 participants experienced a fall and 484 reported an injurious fall in the 12 months prior to baseline assessment. CKD was not significantly associated with falls (OR = 0.95, 95%CI = 0.79-1.14 for eGFR< 60; OR = 1.02, 95%CI = 0.81-1.28 for eGFR< 45; OR = 1.08, 95%CI = 0.74-1.57 for eGFR< 30) or injurious falls (OR = 0.91, 95%CI = 0.67-1.24 for eGFR< 60; OR = 0.93, 95%CI = 0.63-1.37 for eGFR< 45; OR = 1.19, 95%CI = 0.62-2.29 for eGFR< 30). LUTS were found significantly associated with both falls (OR = 1.56, 95%CI = 1.29-1.89) and injurious falls (OR = 1.58, 95%CI = 1.14-2.19), and such associations were confirmed in all multivariable models. Conclusions: Cross-sectional data suggest that CKD may not be associated with history of falls or injurious falls, whereas LUTS is significantly associated with the outcomes. Trial registration: This study was registered on 25th February 2016 at clinicaltrials.gov (NCT02691546).
KW - Falls
KW - Fear of falling
KW - Injurious falls
KW - Kidney function
KW - Older people
KW - Urinary incontinence
UR - http://www.scopus.com/inward/record.url?scp=85092298464&partnerID=8YFLogxK
U2 - 10.1186/s12877-020-01698-2
DO - 10.1186/s12877-020-01698-2
M3 - Article
C2 - 33008307
AN - SCOPUS:85092298464
SN - 1471-2318
VL - 20
JO - BMC Geriatrics
JF - BMC Geriatrics
M1 - 320
ER -