Kingella negevensis shares multiple putative virulence factors with Kingella kingae

Eric A. Porsch, Pablo Yagupsky, Joseph W. St Geme

Research output: Contribution to journalArticlepeer-review

Abstract

Kingella negevensis is a newly described gram-negative bacterium in the Neisseriaceae family and is closely related to Kingella kingae, an important cause of pediatric osteoarticular infections and other invasive diseases. Like K. kingae, K. negevensis can be isolated from the oropharynx of young children, although at a much lower rate. Due to the potential for misidentification as K. kingae, the burden of disease due to K. negevensis is currently unknown. Similarly, there is little known about virulence factors present in K. negevensis and how they compare to virulence factors in K. kingae. Using a variety of approaches, we show that K. negevensis produces many of the same putative virulence factors that are present in K. kingae, including a polysaccharide capsule, a secreted exopolysaccharide, a Knh-like trimeric autotransporter, and type IV pili, suggesting that K. negevensis may have significant pathogenic potential.

Original languageEnglish
Article numbere0241511
JournalPLoS ONE
Volume15
Issue number10 October
DOIs
StatePublished - 1 Oct 2020
Externally publishedYes

Fingerprint

Dive into the research topics of 'Kingella negevensis shares multiple putative virulence factors with Kingella kingae'. Together they form a unique fingerprint.

Cite this