Lack of association between joint hyperlaxity and, I: Panic disorder, and II: Reactivity to carbon dioxide in healthy volunteers

Jonathan Benjamin, Itzhak Z. Ben-Zion, Pinhas Dannon, Shaul Schreiber, Gal Meiri, Andre Ofek, Alex Palatnik

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

This study attempted to replicate previous reports of associations between panic disorder and joint hyperlaxity. The authors also examined possible associations between reacitivity to carbon dioxide (CO2), a model for panic vulnerability, and hyperlaxity in healthy volunteers. One hundred and one patients with DSM-IV panic disorder and 39 healthy volunteers were assessed for hyperlaxity by Beighton's criteria. Healthy volunteers also received two vital capacity inhalations of CO2. Thirteen (13%) patients had five or more hyperlax joints. This rate did not differ from that in the healthy volunteers. Anxiety in healthy volunteers as measured by the NIMH self-rating scale, DSM-IV panic symptom scores, and 100 mm visual analog scales of anxiety, increased after CO2 from a mean of 1.8 to 2.8 (not significant); from 0.5 to 4 (p<0.001) and from 8.7 to 11.6 mm (p<0.1), respectively. There were no associations between responses to CO2 and hyperlaxity.

Original languageEnglish
Pages (from-to)189-192
Number of pages4
JournalHuman Psychopharmacology
Volume16
Issue number2
DOIs
StatePublished - 5 Apr 2001
Externally publishedYes

Keywords

  • Anxiety
  • Hypermobility
  • Joint
  • Joint instability

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