Lack of effect of ECS on rat brain inositol monophosphatase activity and inositol levels and of i.c.v. inositol on ictal and post-ictal length

Y. Patishi; G. Agam; M. Tardov; O. Kofman; R. H. Belmaker

doi:10.1016/0022-3956(95)00036-4

Lack of effect of ECS on rat brain inositol monophosphatase activity and inositol levels and of i.c.v. inositol on ictal and post-ictal length

Y. Patishi, G. Agam, M. Tardov, O. Kofman, R. H. Belmaker

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Lithium (Li) has often been compared to ECT in therapeutic spectrum and mechanism. Inhibition of inositol monophosphatase and reduction of brain inositol are major mechanisms of Li action. Many Li effects in animals and humans are reversible by inositol. We therefore studied interactions of ECS and inositol. ECS in rats did not reduce brain inositol monophosphatase activity or brain inositol levels. Intracerebroventricular injection of 10 mg inositol, a dose that reverses Li effects, had no effect on seizure length or post-ictal length.

Original language	English
Pages (from-to)	39-43
Number of pages	5
Journal	Journal of Psychiatric Research
Volume	30
Issue number	1
DOIs	https://doi.org/10.1016/0022-3956(95)00036-4
State	Published - 1 Jan 1996

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry

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title = "Lack of effect of ECS on rat brain inositol monophosphatase activity and inositol levels and of i.c.v. inositol on ictal and post-ictal length",

abstract = "Lithium (Li) has often been compared to ECT in therapeutic spectrum and mechanism. Inhibition of inositol monophosphatase and reduction of brain inositol are major mechanisms of Li action. Many Li effects in animals and humans are reversible by inositol. We therefore studied interactions of ECS and inositol. ECS in rats did not reduce brain inositol monophosphatase activity or brain inositol levels. Intracerebroventricular injection of 10 mg inositol, a dose that reverses Li effects, had no effect on seizure length or post-ictal length.",

author = "Y. Patishi and G. Agam and M. Tardov and O. Kofman and Belmaker, \{R. H.\}",

note = "Funding Information: Acknowledgements Supported by a grant from the German-Israel Foundation, No. 1-245-098.0292. to R. H. Belmaker and O. Kofman.",

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T1 - Lack of effect of ECS on rat brain inositol monophosphatase activity and inositol levels and of i.c.v. inositol on ictal and post-ictal length

AU - Patishi, Y.

AU - Agam, G.

AU - Tardov, M.

AU - Kofman, O.

AU - Belmaker, R. H.

N1 - Funding Information: Acknowledgements Supported by a grant from the German-Israel Foundation, No. 1-245-098.0292. to R. H. Belmaker and O. Kofman.

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AB - Lithium (Li) has often been compared to ECT in therapeutic spectrum and mechanism. Inhibition of inositol monophosphatase and reduction of brain inositol are major mechanisms of Li action. Many Li effects in animals and humans are reversible by inositol. We therefore studied interactions of ECS and inositol. ECS in rats did not reduce brain inositol monophosphatase activity or brain inositol levels. Intracerebroventricular injection of 10 mg inositol, a dose that reverses Li effects, had no effect on seizure length or post-ictal length.

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Lack of effect of ECS on rat brain inositol monophosphatase activity and inositol levels and of i.c.v. inositol on ictal and post-ictal length

Abstract

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