Lack of effect of vitamin E on serum creatine phosphokinase in patients with long-term tardive dyskinesia

A. Dorevitch, V. Lerner, M. Shalfman, M. Kalian

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Changes in serum creatine phosphokinase have been associated with exacerbation of tardive dyskinesia. Vitamin E, a drug suggested to be effective in the treatment of tardive dyskinesia, has been implicated as a possible cause of increased creatine phosphokinase levels. Ten patients with long-term tardive dyskinesia were treated with vitamin E in a double-blind, placebo-controlled crossover study. Vitamin E blood levels and creatine phosphokinase serum levels were monitored at various phases during the study. There were no significant differences between vitamin E and placebo treated patients in their abilities to affect tardive dyskinesia or to influence creatine phosphokinase levels. These data do not support the hypothesis that administration of vitamin E may alter creatine phosphokinase levels in patients with long-term tardive dyskinesia.

Original languageEnglish
Pages (from-to)171-173
Number of pages3
JournalInternational Clinical Psychopharmacology
Volume12
Issue number3
DOIs
StatePublished - 1 Jan 1997
Externally publishedYes

Keywords

  • Creatine phosphokinase
  • Tardive dyskinesia
  • Vitamin E

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Pharmacology (medical)

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