Lack of effectiveness of forskolin or inositol as antidote in lithium toxicity

Z. Kaplan; G. Schreiber; R. H. Belmaker

doi:10.1007/BF01250239

Lack of effectiveness of forskolin or inositol as antidote in lithium toxicity

Z. Kaplan, G. Schreiber, R. H. Belmaker

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Forskolin, a direct adenylate cyclase stimulator, was suggested as a possible antidote to lithium toxicity, since lithium inhibits cyclic AMP accumulation. Inositol, a sugar isomer reduced in lithium treatment due to inhibition of inositol-1-phosphatase, was suggested as a possible antidote to lithium toxicity. Both were ineffective in a mouse model.

Original language	English
Pages (from-to)	167-170
Number of pages	4
Journal	Journal of Neural Transmission
Volume	72
Issue number	2
DOIs	https://doi.org/10.1007/BF01250239
State	Published - 1 Jun 1988
Externally published	Yes

Keywords

Lithium
forskolin
inositol
toxicity

ASJC Scopus subject areas

Neurology
Clinical Neurology
Psychiatry and Mental health
Biological Psychiatry

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10.1007/BF01250239

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title = "Lack of effectiveness of forskolin or inositol as antidote in lithium toxicity",

abstract = "Forskolin, a direct adenylate cyclase stimulator, was suggested as a possible antidote to lithium toxicity, since lithium inhibits cyclic AMP accumulation. Inositol, a sugar isomer reduced in lithium treatment due to inhibition of inositol-1-phosphatase, was suggested as a possible antidote to lithium toxicity. Both were ineffective in a mouse model.",

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year = "1988",

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AU - Kaplan, Z.

AU - Schreiber, G.

AU - Belmaker, R. H.

PY - 1988/6/1

Y1 - 1988/6/1

N2 - Forskolin, a direct adenylate cyclase stimulator, was suggested as a possible antidote to lithium toxicity, since lithium inhibits cyclic AMP accumulation. Inositol, a sugar isomer reduced in lithium treatment due to inhibition of inositol-1-phosphatase, was suggested as a possible antidote to lithium toxicity. Both were ineffective in a mouse model.

AB - Forskolin, a direct adenylate cyclase stimulator, was suggested as a possible antidote to lithium toxicity, since lithium inhibits cyclic AMP accumulation. Inositol, a sugar isomer reduced in lithium treatment due to inhibition of inositol-1-phosphatase, was suggested as a possible antidote to lithium toxicity. Both were ineffective in a mouse model.

KW - Lithium

KW - forskolin

KW - inositol

KW - toxicity

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DO - 10.1007/BF01250239

M3 - Article

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JO - Journal of Neural Transmission

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ER -

Lack of effectiveness of forskolin or inositol as antidote in lithium toxicity

Abstract

Keywords

ASJC Scopus subject areas

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