Lack of proliferation to alloantigen in a sibling of two infants with severe combined immunodeficiency (SCID)

Z. Spirer; V. Zakuth; E. Tzechoval; S. Diamant; S. Segal

doi:10.1016/0090-1229(82)90239-2

Lack of proliferation to alloantigen in a sibling of two infants with severe combined immunodeficiency (SCID)

Z. Spirer, V. Zakuth, E. Tzechoval, S. Diamant, S. Segal

Research output: Contribution to journal › Article › peer-review

Abstract

A 6-year-old female sister of two infants who died from complications caused by severe combined immunodeficiency (SCID), is reported. Although clinically asymptomatic, she showed the following laboratory immunological abnormalities: negative MLC response, decreased number of E-rosettes, decreased response to PWM and Con A in spite of normal response to PHA, a high number of IgD-positive B cells, and normal immunoglobulin level. The importance of these findings is stressed and similar models are discussed as examples of complexity of the immune functions in animals and men.

Original language	English
Pages (from-to)	286-291
Number of pages	6
Journal	Clinical Immunology and Immunopathology
Volume	24
Issue number	2
DOIs	https://doi.org/10.1016/0090-1229(82)90239-2
State	Published - 1 Jan 1982
Externally published	Yes

ASJC Scopus subject areas

Immunology and Allergy
Pathology and Forensic Medicine
Immunology

Access to Document

10.1016/0090-1229(82)90239-2

Cite this

@article{00c66906d6e84b3aa6f1b72c4e8824fd,

title = "Lack of proliferation to alloantigen in a sibling of two infants with severe combined immunodeficiency (SCID)",

abstract = "A 6-year-old female sister of two infants who died from complications caused by severe combined immunodeficiency (SCID), is reported. Although clinically asymptomatic, she showed the following laboratory immunological abnormalities: negative MLC response, decreased number of E-rosettes, decreased response to PWM and Con A in spite of normal response to PHA, a high number of IgD-positive B cells, and normal immunoglobulin level. The importance of these findings is stressed and similar models are discussed as examples of complexity of the immune functions in animals and men.",

author = "Z. Spirer and V. Zakuth and E. Tzechoval and S. Diamant and S. Segal",

year = "1982",

month = jan,

day = "1",

doi = "10.1016/0090-1229(82)90239-2",

language = "English",

volume = "24",

pages = "286--291",

journal = "Clinical Immunology and Immunopathology",

issn = "0090-1229",

publisher = "Academic Press Inc.",

number = "2",

}

TY - JOUR

T1 - Lack of proliferation to alloantigen in a sibling of two infants with severe combined immunodeficiency (SCID)

AU - Spirer, Z.

AU - Zakuth, V.

AU - Tzechoval, E.

AU - Diamant, S.

AU - Segal, S.

PY - 1982/1/1

Y1 - 1982/1/1

N2 - A 6-year-old female sister of two infants who died from complications caused by severe combined immunodeficiency (SCID), is reported. Although clinically asymptomatic, she showed the following laboratory immunological abnormalities: negative MLC response, decreased number of E-rosettes, decreased response to PWM and Con A in spite of normal response to PHA, a high number of IgD-positive B cells, and normal immunoglobulin level. The importance of these findings is stressed and similar models are discussed as examples of complexity of the immune functions in animals and men.

AB - A 6-year-old female sister of two infants who died from complications caused by severe combined immunodeficiency (SCID), is reported. Although clinically asymptomatic, she showed the following laboratory immunological abnormalities: negative MLC response, decreased number of E-rosettes, decreased response to PWM and Con A in spite of normal response to PHA, a high number of IgD-positive B cells, and normal immunoglobulin level. The importance of these findings is stressed and similar models are discussed as examples of complexity of the immune functions in animals and men.

UR - http://www.scopus.com/inward/record.url?scp=0019973754&partnerID=8YFLogxK

U2 - 10.1016/0090-1229(82)90239-2

DO - 10.1016/0090-1229(82)90239-2

M3 - Article

C2 - 6214356

AN - SCOPUS:0019973754

SN - 0090-1229

VL - 24

SP - 286

EP - 291

JO - Clinical Immunology and Immunopathology

JF - Clinical Immunology and Immunopathology

IS - 2

ER -

Lack of proliferation to alloantigen in a sibling of two infants with severe combined immunodeficiency (SCID)

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this