TY - JOUR
T1 - Langerhans cell histiocytosis in a premature baby presenting with skin-isolated disease
T2 - Case report and literature review
AU - Aviner, Shraga
AU - Ronen, Meir
AU - London, Daniel
AU - Tobar, Ana
AU - Zangen, Shmuel
PY - 2008/12/1
Y1 - 2008/12/1
N2 - Langerhans cell histiocytosis (LCH) in premature babies is extremely rare as is a vesicular skin rash, while gastrointestinal involvement is associated with a poor outcome. We report a case of LCH in a premature baby presented with isolated vesiculo-papulo-macular skin lesions and insidiously developed gastrointestinal symptoms, haematological and severe pulmonary involvement. We also reviewed a few cases of LCH in premature babies in the English language medical literature. LCH in preterm babies appears to be a severe systemic disease, usually lethal in-utero or post delivery. Conclusion: Careful observation should be applied to newborns with skin-only Langerhans cell histiocytosis in order to identify in time progression to potentially fatal systemic disease.
AB - Langerhans cell histiocytosis (LCH) in premature babies is extremely rare as is a vesicular skin rash, while gastrointestinal involvement is associated with a poor outcome. We report a case of LCH in a premature baby presented with isolated vesiculo-papulo-macular skin lesions and insidiously developed gastrointestinal symptoms, haematological and severe pulmonary involvement. We also reviewed a few cases of LCH in premature babies in the English language medical literature. LCH in preterm babies appears to be a severe systemic disease, usually lethal in-utero or post delivery. Conclusion: Careful observation should be applied to newborns with skin-only Langerhans cell histiocytosis in order to identify in time progression to potentially fatal systemic disease.
KW - Gastrointestinal tract
KW - Langerhans cell histiocytosis
KW - Premature baby
UR - http://www.scopus.com/inward/record.url?scp=55749085786&partnerID=8YFLogxK
U2 - 10.1111/j.1651-2227.2008.00999.x
DO - 10.1111/j.1651-2227.2008.00999.x
M3 - Article
C2 - 18754823
AN - SCOPUS:55749085786
SN - 0803-5253
VL - 97
SP - 1751
EP - 1754
JO - Acta Paediatrica, International Journal of Paediatrics
JF - Acta Paediatrica, International Journal of Paediatrics
IS - 12
ER -
