Langerhans cell histiocytosis with periorbital cellulitis

Jaime Levy, Tova Monos, Joseph Kapelushnik, Esther Maor, Michael Nash, Tova Lifshitz

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


OBJECTIVE: To report a case of Langerhans cell histiocytosis presenting as periorbital cellulitis. DESIGN: Interventional case report. METHODS: A 3-year-old girl presented with periorbital swelling of the right upper lid laterally of two days' duration. A history of recent eye trauma was reported. RESULTS: Computed tomography showed a soft tissue mass that eroded the frontozygomatic suture. The lesion was debulked through a lateral orbitotomy. Electron microscopy disclosed Birbeck granules. Immunohistochemistry stained positively for CD68 and CD1a antigenic determinants. CONCLUSIONS: Although rare, Langerhans cell histiocytosis can cause acute periorbital cellulitis in children. Trauma can induce an inflammatory response, allowing for earlier diagnosis of the orbital lesion.

Original languageEnglish
Pages (from-to)939-942
Number of pages4
JournalAmerican Journal of Ophthalmology
Issue number5
StatePublished - 1 Jan 2003
Externally publishedYes

ASJC Scopus subject areas

  • Ophthalmology


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