Langerhans cell histiocytosis with periorbital cellulitis

Jaime Levy; Tova Monos; Joseph Kapelushnik; Esther Maor; Michael Nash; Tova Lifshitz

doi:10.1016/S0002-9394(03)00487-2

Langerhans cell histiocytosis with periorbital cellulitis

Jaime Levy, Tova Monos, Joseph Kapelushnik, Esther Maor, Michael Nash, Tova Lifshitz

Medical School for International Health

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

OBJECTIVE: To report a case of Langerhans cell histiocytosis presenting as periorbital cellulitis. DESIGN: Interventional case report. METHODS: A 3-year-old girl presented with periorbital swelling of the right upper lid laterally of two days' duration. A history of recent eye trauma was reported. RESULTS: Computed tomography showed a soft tissue mass that eroded the frontozygomatic suture. The lesion was debulked through a lateral orbitotomy. Electron microscopy disclosed Birbeck granules. Immunohistochemistry stained positively for CD68 and CD1a antigenic determinants. CONCLUSIONS: Although rare, Langerhans cell histiocytosis can cause acute periorbital cellulitis in children. Trauma can induce an inflammatory response, allowing for earlier diagnosis of the orbital lesion.

Original language	English
Pages (from-to)	939-942
Number of pages	4
Journal	American Journal of Ophthalmology
Volume	136
Issue number	5
DOIs	https://doi.org/10.1016/S0002-9394(03)00487-2
State	Published - 1 Jan 2003

ASJC Scopus subject areas

Ophthalmology

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title = "Langerhans cell histiocytosis with periorbital cellulitis",

abstract = "OBJECTIVE: To report a case of Langerhans cell histiocytosis presenting as periorbital cellulitis. DESIGN: Interventional case report. METHODS: A 3-year-old girl presented with periorbital swelling of the right upper lid laterally of two days' duration. A history of recent eye trauma was reported. RESULTS: Computed tomography showed a soft tissue mass that eroded the frontozygomatic suture. The lesion was debulked through a lateral orbitotomy. Electron microscopy disclosed Birbeck granules. Immunohistochemistry stained positively for CD68 and CD1a antigenic determinants. CONCLUSIONS: Although rare, Langerhans cell histiocytosis can cause acute periorbital cellulitis in children. Trauma can induce an inflammatory response, allowing for earlier diagnosis of the orbital lesion.",

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T1 - Langerhans cell histiocytosis with periorbital cellulitis

AU - Levy, Jaime

AU - Monos, Tova

AU - Kapelushnik, Joseph

AU - Maor, Esther

AU - Nash, Michael

AU - Lifshitz, Tova

PY - 2003/1/1

Y1 - 2003/1/1

N2 - OBJECTIVE: To report a case of Langerhans cell histiocytosis presenting as periorbital cellulitis. DESIGN: Interventional case report. METHODS: A 3-year-old girl presented with periorbital swelling of the right upper lid laterally of two days' duration. A history of recent eye trauma was reported. RESULTS: Computed tomography showed a soft tissue mass that eroded the frontozygomatic suture. The lesion was debulked through a lateral orbitotomy. Electron microscopy disclosed Birbeck granules. Immunohistochemistry stained positively for CD68 and CD1a antigenic determinants. CONCLUSIONS: Although rare, Langerhans cell histiocytosis can cause acute periorbital cellulitis in children. Trauma can induce an inflammatory response, allowing for earlier diagnosis of the orbital lesion.

AB - OBJECTIVE: To report a case of Langerhans cell histiocytosis presenting as periorbital cellulitis. DESIGN: Interventional case report. METHODS: A 3-year-old girl presented with periorbital swelling of the right upper lid laterally of two days' duration. A history of recent eye trauma was reported. RESULTS: Computed tomography showed a soft tissue mass that eroded the frontozygomatic suture. The lesion was debulked through a lateral orbitotomy. Electron microscopy disclosed Birbeck granules. Immunohistochemistry stained positively for CD68 and CD1a antigenic determinants. CONCLUSIONS: Although rare, Langerhans cell histiocytosis can cause acute periorbital cellulitis in children. Trauma can induce an inflammatory response, allowing for earlier diagnosis of the orbital lesion.

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Langerhans cell histiocytosis with periorbital cellulitis

Abstract

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