Laparoscopic Management of an Invasive Mole Perforating the Uterus

Leonti Grin, Ahmed Namazov, Michael Volodarsky, Eyal Anteby, Ofer Lavie, Ofer Gemer

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Study Objective To show the possibility of conservative laparoscopic management in a case of invasive mole perforating the uterus. Design Video with explanations. Setting An invasive mole is a potentially life-threatening complication of gestational trophoblastic disease [1]. This is a case of a 24-year-old female presenting with abdominal pain and vaginal bleeding. There have been several previous reports of cases of uterine perforation by an invasive mole, all of which were managed with abdominal hysterectomy [2–7]. To our knowledge, this is the first report of an invasive mole perforation with active bleeding managed by laparoscopy without hysterectomy. Interventions Sonography revealed a large amount of fluid and a 3 × 3-cm heterogeneous lesion next to the posterior uterine wall. Her hemoglobin level dropped from 10.6 mg/dL to 8.6 mg/dL, and her β-human chorionic gonadotropin level was 19,004 mIU/mL. On laparoscopy, ∼2500 mL of hemoperitoneum was found, along with an actively bleeding bulging mass in the posterior uterine wall. This mass was dissected, and hemostasis was secured with sutures and electrocoagulation. Pathology confirmed the diagnosis of a complete mole. After surgery, the patient was treated with 5 courses of a methotrexate-folinic acid regimen. Her recovery was uneventful. Conclusion Uterine perforation by an invasive mole can be managed conservatively with laparoscopic surgery and postoperative chemotherapy. The transmural lesion will increase the risk of future uterine rupture during pregnancy in this patient.

Original languageEnglish
Pages (from-to)199-200
Number of pages2
JournalJournal of Minimally Invasive Gynecology
Issue number2
StatePublished - 1 Feb 2017


  • Invasive mole
  • Laparoscopy
  • Uterine rupture

ASJC Scopus subject areas

  • Obstetrics and Gynecology


Dive into the research topics of 'Laparoscopic Management of an Invasive Mole Perforating the Uterus'. Together they form a unique fingerprint.

Cite this