Larvicidal activity of saponin containing extracts and fractions of fruit mesocarp of Balanites aegyptiaca

Zeev Wiesman, Bishnu P. Chapagain

Research output: Contribution to journalArticlepeer-review

61 Scopus citations

Abstract

Chloroform, ethyl acetate, butanol and methanol extracts of fruit mesocarp of Balanites aegyptiaca and five fractions from the methanol extract were tested against the Aedes aegypti mosquito larvae. All extracts showed larvicidal effects however the highest larval mortality was found in methanol extract. One fraction obtained from the silica gel column chromatography of the latter was found most effective for larval mortality. This fraction also interfered with adult emergence. A concentration of 0.0014% (w/v) of this active fraction showed inhibition of the 50% of the test larval population from emerging adults (EC50). The analysis of total saponin content of these tested extracts and fractions revealed a strong correlation between saponin content and larval mortality.

Original languageEnglish
Pages (from-to)420-424
Number of pages5
JournalFitoterapia
Volume77
Issue number6
DOIs
StatePublished - 1 Jan 2006
Externally publishedYes

Keywords

  • Aedes aegypti
  • Balanites aegyptiaca
  • Larvicidal activity
  • Saponins

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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