Le trouble bipolaire associé à une autre maladie auto-immune — le pemphigus: une étude dans la population

Translated title of the contribution: Bipolar Disorder Associated with Another Autoimmune Disease—Pemphigus: A Population-based Study

Khalaf Kridin, Shira Zelber-Sagi, Doron Comaneshter, Arnon D. Cohen

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Objectives: Recent evidence suggests a notable role for inflammation and immune dysregulation in the neuroprogression of bipolar disorders (BD). Several autoimmune comorbidities have been reported in association with BD. However, the epidemiological relationship between pemphigus and BD has not yet been elucidated. We aimed to estimate the association between pemphigus and BD using a large-scale, real-life computerized database. Methods: Data for this study were retrieved from the database of the Clalit Health Services, the largest, state-mandated, health service organization in Israel. This study was designed as a cross-sectional study. The proportion of patients with BD was compared between patients diagnosed with pemphigus and age-, sex-, and ethnicity-matched control subjects. A logistic regression model was performed to estimate how pemphigus and other covariates contributed as risk factors for BD. Results: A total of 1,985 pemphigus cases and 9,874 controls were included in the study. The prevalence of BD was greater in cases with pemphigus than in controls (1.0% v. 0.5%, respectively; P = 0.023). This coexistence was more prominent among patients of Jewish ethnicity. After controlling for confounders, such as age, sex, ethnicity, socioeconomic status, drug abuse, alcohol abuse, smoking, healthcare utilization, and comorbidities, pemphigus demonstrated a substantial independent association with BD (OR, 1.7; 95% CI, 1.0 to 2.9). Conclusions: Pemphigus is significantly associated with BD. Patients with pemphigus should be assessed for comorbid BD. Experimental research is needed to better recognize the biological mechanisms underlying this observation.

Translated title of the contributionBipolar Disorder Associated with Another Autoimmune Disease—Pemphigus: A Population-based Study
Original languageFrench
Pages (from-to)474-480
Number of pages7
JournalCanadian Journal of Psychiatry
Volume63
Issue number7
DOIs
StatePublished - 1 Jul 2018

Keywords

  • Bipolar disorder
  • autoimmune
  • cytokines
  • inflammation
  • pemphigus

ASJC Scopus subject areas

  • Psychiatry and Mental health

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