Leishmania major: Antileishmanial activity of methylbenzethonium chloride

J. El-On, G. Messer

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

Methylbenzethonium chloride (MBCl) decreased the growth of Leishmania major promastigotes and amastigotes in vitro. This decrease occurred during 4 days of exposure to the drug at concentrations of 0.1 to 2.5 μg ml-1. MBCl at 2 μg ml-1 killed almost 100% of the free living promastigotes and 87% of amastigotes within 4 days of treatment. Electron microscopy studies showed marked swelling of mitochondria in treated parasites. A possible additional effect on the parasite surface membrane is discussed.

Original languageEnglish
Pages (from-to)1110-1116
Number of pages7
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume35
Issue number6
DOIs
StatePublished - 1 Jan 1986

Fingerprint

Dive into the research topics of 'Leishmania major: Antileishmanial activity of methylbenzethonium chloride'. Together they form a unique fingerprint.

Cite this