Leishmania major: Antileishmanial activity of methylbenzethonium chloride

J. El-On; G. Messer

doi:10.4269/ajtmh.1986.35.1110

Leishmania major: Antileishmanial activity of methylbenzethonium chloride

J. El-On, G. Messer

Basic Sciences Divisions

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30 Scopus citations

Abstract

Methylbenzethonium chloride (MBCl) decreased the growth of Leishmania major promastigotes and amastigotes in vitro. This decrease occurred during 4 days of exposure to the drug at concentrations of 0.1 to 2.5 μg ml^-1. MBCl at 2 μg ml^-1 killed almost 100% of the free living promastigotes and 87% of amastigotes within 4 days of treatment. Electron microscopy studies showed marked swelling of mitochondria in treated parasites. A possible additional effect on the parasite surface membrane is discussed.

Original language	English
Pages (from-to)	1110-1116
Number of pages	7
Journal	American Journal of Tropical Medicine and Hygiene
Volume	35
Issue number	6
DOIs	https://doi.org/10.4269/ajtmh.1986.35.1110
State	Published - 1 Jan 1986

ASJC Scopus subject areas

Parasitology
Infectious Diseases
Virology

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abstract = "Methylbenzethonium chloride (MBCl) decreased the growth of Leishmania major promastigotes and amastigotes in vitro. This decrease occurred during 4 days of exposure to the drug at concentrations of 0.1 to 2.5 μg ml-1. MBCl at 2 μg ml-1 killed almost 100% of the free living promastigotes and 87% of amastigotes within 4 days of treatment. Electron microscopy studies showed marked swelling of mitochondria in treated parasites. A possible additional effect on the parasite surface membrane is discussed.",

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Leishmania major: Antileishmanial activity of methylbenzethonium chloride

Abstract

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