Leishmania major: Excreted factor, calcium ions, and the survival of amastigotes

Yael Eilam, Joseph El-On, Dan T. Spira

Research output: Contribution to journalArticlepeer-review

42 Scopus citations

Abstract

Mouse macrophages infected with amastigotes of Leishmania major contain about 40% more intracellular exchangeable calcium than control macrophages. Similar elevation of intracellular exchangeable calcium was observed in macrophages engulfing red blood cells coated with purified excreted factor from L. major. The rate of cytolysis of red blood cells coated with excreted factor was significantly lower than that of uncoated controls. Excreted factor strongly binds calcium; thus, the possible role of a microenvironment rich in calcium bound to excreted factor within the phagolysosome in protecting the amastigotes may be considered.

Original languageEnglish
Pages (from-to)161-168
Number of pages8
JournalExperimental Parasitology
Volume59
Issue number2
DOIs
StatePublished - 1 Jan 1985
Externally publishedYes

Keywords

  • Amastigote
  • Calcium ions
  • Cytolysis
  • Hemoflagellate
  • Leishmania major
  • Macrophage
  • Mouse
  • Phagolysosomes
  • Protozoa, parasitic

ASJC Scopus subject areas

  • Parasitology
  • Immunology
  • Infectious Diseases

Fingerprint

Dive into the research topics of 'Leishmania major: Excreted factor, calcium ions, and the survival of amastigotes'. Together they form a unique fingerprint.

Cite this