Leishmania parasites act as a Trojan horse that paralyzes the translation system of host macrophages

Michal Shapira; Alexandra Zinoviev

doi:10.1016/j.chom.2011.04.004

Leishmania parasites act as a Trojan horse that paralyzes the translation system of host macrophages

Michal Shapira, Alexandra Zinoviev

Department of Life Sciences

Research output: Contribution to journal › Short survey › peer-review

8 Scopus citations

Abstract

GP63 is an abundant GPI-anchored surface metalloprotease of Leishmania. Jaramillo et al. (2011) show that GP63 manipulates the translation system of host macrophages by cleaving mTOR, which leads to 4E-BP1 dephosphorylation. This study pioneers the observation that Leishmania parasites metabolically paralyze their host cells using an elegant translation shutoff mechanism.

Original language	English
Pages (from-to)	257-259
Number of pages	3
Journal	Cell Host and Microbe
Volume	9
Issue number	4
DOIs	https://doi.org/10.1016/j.chom.2011.04.004
State	Published - 21 Apr 2011

ASJC Scopus subject areas

Parasitology
Microbiology
Virology

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10.1016/j.chom.2011.04.004

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title = "Leishmania parasites act as a Trojan horse that paralyzes the translation system of host macrophages",

abstract = "GP63 is an abundant GPI-anchored surface metalloprotease of Leishmania. Jaramillo et al. (2011) show that GP63 manipulates the translation system of host macrophages by cleaving mTOR, which leads to 4E-BP1 dephosphorylation. This study pioneers the observation that Leishmania parasites metabolically paralyze their host cells using an elegant translation shutoff mechanism.",

author = "Michal Shapira and Alexandra Zinoviev",

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AU - Shapira, Michal

AU - Zinoviev, Alexandra

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N2 - GP63 is an abundant GPI-anchored surface metalloprotease of Leishmania. Jaramillo et al. (2011) show that GP63 manipulates the translation system of host macrophages by cleaving mTOR, which leads to 4E-BP1 dephosphorylation. This study pioneers the observation that Leishmania parasites metabolically paralyze their host cells using an elegant translation shutoff mechanism.

AB - GP63 is an abundant GPI-anchored surface metalloprotease of Leishmania. Jaramillo et al. (2011) show that GP63 manipulates the translation system of host macrophages by cleaving mTOR, which leads to 4E-BP1 dephosphorylation. This study pioneers the observation that Leishmania parasites metabolically paralyze their host cells using an elegant translation shutoff mechanism.

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U2 - 10.1016/j.chom.2011.04.004

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C2 - 21501824

AN - SCOPUS:79955068929

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JO - Cell Host and Microbe

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ER -

Leishmania parasites act as a Trojan horse that paralyzes the translation system of host macrophages

Abstract

ASJC Scopus subject areas

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