Leishmania parasites act as a Trojan horse that paralyzes the translation system of host macrophages

Michal Shapira, Alexandra Zinoviev

Research output: Contribution to journalShort surveypeer-review

7 Scopus citations

Abstract

GP63 is an abundant GPI-anchored surface metalloprotease of Leishmania. Jaramillo et al. (2011) show that GP63 manipulates the translation system of host macrophages by cleaving mTOR, which leads to 4E-BP1 dephosphorylation. This study pioneers the observation that Leishmania parasites metabolically paralyze their host cells using an elegant translation shutoff mechanism.

Original languageEnglish
Pages (from-to)257-259
Number of pages3
JournalCell Host and Microbe
Volume9
Issue number4
DOIs
StatePublished - 21 Apr 2011

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Virology

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