Leishmania, Stress Response in

M. Shapira

doi:10.1016/B978-012373947-6.00236-1

Leishmania, Stress Response in

M. Shapira

Department of Life Sciences

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

Leishmania parasites cycle between sand fly vectors and mammalian hosts, thus experiencing a wide range of temperatures and pH values as well as coping with oxidative stress. These environmental stress conditions trigger stage differentiation and a pattern of developmental gene expression. Despite their ability to survive extreme conditions, the parasites are sensitive to temperatures above a certain threshold, above which cell death occurs. Stage-specific gene regulation occurs exclusively by posttranscriptional mechanisms, including RNA processing, stability, and translation, with the various heat shock genes serving as ideal model systems for this unique group of ancient eukaryotes. © 2007

Original language	English
Title of host publication	Encyclopedia of Stress
Publisher	Elsevier Inc.
Pages	579-584
Number of pages	6
ISBN (Print)	9780123739476
DOIs	https://doi.org/10.1016/B978-012373947-6.00236-1
State	Published - 1 Jan 2007

ASJC Scopus subject areas

General Neuroscience
General Psychology

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10.1016/B978-012373947-6.00236-1

Cite this

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Leishmania, Stress Response in

Abstract

ASJC Scopus subject areas

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