TY - JOUR
T1 - Lemongrass essential oil components with antimicrobial and anticancer activities
AU - Mukarram, Mohammad
AU - Choudhary, Sadaf
AU - Khan, Mo Ahamad
AU - Poltronieri, Palmiro
AU - Khan, M. Masroor A.
AU - Ali, Jamin
AU - Kurjak, Daniel
AU - Shahid, Mohd
N1 - Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2022/1/1
Y1 - 2022/1/1
N2 - The prominent cultivation of lemongrass (Cymbopogon spp.) relies on the pharmacological incentives of its essential oil. Lemongrass essential oil (LEO) carries a significant amount of numerous bioactive compounds, such as citral (mixture of geranial and neral), isoneral, isogeranial, geraniol, geranyl acetate, citronellal, citronellol, germacrene-D, and elemol, in addition to other bioactive compounds. These components confer various pharmacological actions to LEO, including antifungal, antibacterial, antiviral, anticancer, and antioxidant properties. These LEO attributes are commercially exploited in the pharmaceutical, cosmetics, and food preservations industries. Furthermore, the application of LEO in the treatment of cancer opens a new vista in the field of therapeutics. Although different LEO components have shown promising anticancer activities in vitro, their effects have not yet been assessed in the human system. Hence, further studies on the anticancer mechanisms conferred by LEO components are required. The present review intends to provide a timely discussion on the relevance of LEO in combating cancer and sustaining human healthcare, as well as in food industry applications.
AB - The prominent cultivation of lemongrass (Cymbopogon spp.) relies on the pharmacological incentives of its essential oil. Lemongrass essential oil (LEO) carries a significant amount of numerous bioactive compounds, such as citral (mixture of geranial and neral), isoneral, isogeranial, geraniol, geranyl acetate, citronellal, citronellol, germacrene-D, and elemol, in addition to other bioactive compounds. These components confer various pharmacological actions to LEO, including antifungal, antibacterial, antiviral, anticancer, and antioxidant properties. These LEO attributes are commercially exploited in the pharmaceutical, cosmetics, and food preservations industries. Furthermore, the application of LEO in the treatment of cancer opens a new vista in the field of therapeutics. Although different LEO components have shown promising anticancer activities in vitro, their effects have not yet been assessed in the human system. Hence, further studies on the anticancer mechanisms conferred by LEO components are required. The present review intends to provide a timely discussion on the relevance of LEO in combating cancer and sustaining human healthcare, as well as in food industry applications.
KW - Anticancer
KW - Antimicrobial
KW - Antioxidants
KW - Cancer signalling
KW - Citral
KW - Cymbopogon
KW - Essential oil
UR - http://www.scopus.com/inward/record.url?scp=85121463434&partnerID=8YFLogxK
U2 - 10.3390/antiox11010020
DO - 10.3390/antiox11010020
M3 - Article
C2 - 35052524
AN - SCOPUS:85121463434
SN - 2076-3921
VL - 11
JO - Antioxidants
JF - Antioxidants
IS - 1
M1 - 20
ER -
