TY - JOUR
T1 - Leptin restores plasma cholesterol, glucose and weight loss induced by IFNα treatment
AU - Birk, Ruth Z.
AU - Rubinstein, Menachem
N1 - Funding Information:
We thank Sara Barak for excellent technical assistance. M.R. is the Edna and Maurice Weiss Professor of Cytokine Research. This study was supported by the Serono Group of companies.
PY - 2007/4/13
Y1 - 2007/4/13
N2 - Leptin, an adipokine, a major regulator of food intake, was recently suggested to play a role in immune response. We previously showed that weight reduction following IFNα therapy is due, at least in part, to direct induction of adipose tissue apoptosis. We now studied the effect of leptin on IFNα treated adipocytes in vitro and in vivo. Diet induced obese C57/B6 mice were treated continually with recombinant (r) IFNαA/D + leptin (100 U/g body weight + 10 μg/day, respectably) or leptin (10 μg/day) alone for 8 days. Co-administration of IFNαA/D + leptin significantly reduced plasma cholesterol (P < 0.001), glucose (P < 0.007) and pro-apoptotic protein levels (P < 0.05). Additionally, co-administration prevented loss of body weight due to adipocyte apoptosis. Thus, leptin co-administration with IFNαA/D decreases some of the side effects of IFNα administration such as weight loss, cholesterol and glucose levels.
AB - Leptin, an adipokine, a major regulator of food intake, was recently suggested to play a role in immune response. We previously showed that weight reduction following IFNα therapy is due, at least in part, to direct induction of adipose tissue apoptosis. We now studied the effect of leptin on IFNα treated adipocytes in vitro and in vivo. Diet induced obese C57/B6 mice were treated continually with recombinant (r) IFNαA/D + leptin (100 U/g body weight + 10 μg/day, respectably) or leptin (10 μg/day) alone for 8 days. Co-administration of IFNαA/D + leptin significantly reduced plasma cholesterol (P < 0.001), glucose (P < 0.007) and pro-apoptotic protein levels (P < 0.05). Additionally, co-administration prevented loss of body weight due to adipocyte apoptosis. Thus, leptin co-administration with IFNαA/D decreases some of the side effects of IFNα administration such as weight loss, cholesterol and glucose levels.
KW - Adipocytes
KW - Body weight
KW - Diet-induce obesity
KW - IFNα
KW - Leptin
UR - http://www.scopus.com/inward/record.url?scp=33847298980&partnerID=8YFLogxK
U2 - 10.1016/j.bbrc.2007.01.197
DO - 10.1016/j.bbrc.2007.01.197
M3 - Article
C2 - 17307134
AN - SCOPUS:33847298980
SN - 0006-291X
VL - 355
SP - 626
EP - 631
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 3
ER -
