Leukocyte adherence inhibition assay in the diagnosis and follow-up of colorectal cancer patients

Z. Weisman; A. Shani; A. Fink; A. Shindel; A. Sela; U. Wechsler; R. Pfeffermann; Z. Bentwich

doi:10.1159/000226098

Leukocyte adherence inhibition assay in the diagnosis and follow-up of colorectal cancer patients

Z. Weisman, A. Shani, A. Fink, A. Shindel, A. Sela, U. Wechsler, R. Pfeffermann, Z. Bentwich

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Antitumor immune response to colorectal cancer extract was tested by the lube leukocyte adherence inhibition (LAI) assay. Of 70 colorectal cancer patients, 38 (54%) were LAI-positive. In contrast, 15 of 159 (9%) healthy individuals and 2 of 28 (7%) patients with nonmalignant diseases were positive. The LAI activity disappeared a few months after surgery and remained negative in patients with no evidence of disease as well as in patients with disseminated progressed disease. A change of LAI from negative to positive during the follow up period correlated in some cases with the recurrence of the disease, but was observed also in cases with no clinical evidence of disease.

Original language	English
Pages (from-to)	23-26
Number of pages	4
Journal	Oncology
Volume	43
Issue number	1
DOIs	https://doi.org/10.1159/000226098
State	Published - 1 Jan 1986
Externally published	Yes

Keywords

Colorectal cancer
Leukocyte adherence inhibition

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1159/000226098

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title = "Leukocyte adherence inhibition assay in the diagnosis and follow-up of colorectal cancer patients",

abstract = "Antitumor immune response to colorectal cancer extract was tested by the lube leukocyte adherence inhibition (LAI) assay. Of 70 colorectal cancer patients, 38 (54%) were LAI-positive. In contrast, 15 of 159 (9%) healthy individuals and 2 of 28 (7%) patients with nonmalignant diseases were positive. The LAI activity disappeared a few months after surgery and remained negative in patients with no evidence of disease as well as in patients with disseminated progressed disease. A change of LAI from negative to positive during the follow up period correlated in some cases with the recurrence of the disease, but was observed also in cases with no clinical evidence of disease.",

keywords = "Colorectal cancer, Leukocyte adherence inhibition",

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AU - Weisman, Z.

AU - Shani, A.

AU - Fink, A.

AU - Shindel, A.

AU - Sela, A.

AU - Wechsler, U.

AU - Pfeffermann, R.

AU - Bentwich, Z.

PY - 1986/1/1

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N2 - Antitumor immune response to colorectal cancer extract was tested by the lube leukocyte adherence inhibition (LAI) assay. Of 70 colorectal cancer patients, 38 (54%) were LAI-positive. In contrast, 15 of 159 (9%) healthy individuals and 2 of 28 (7%) patients with nonmalignant diseases were positive. The LAI activity disappeared a few months after surgery and remained negative in patients with no evidence of disease as well as in patients with disseminated progressed disease. A change of LAI from negative to positive during the follow up period correlated in some cases with the recurrence of the disease, but was observed also in cases with no clinical evidence of disease.

AB - Antitumor immune response to colorectal cancer extract was tested by the lube leukocyte adherence inhibition (LAI) assay. Of 70 colorectal cancer patients, 38 (54%) were LAI-positive. In contrast, 15 of 159 (9%) healthy individuals and 2 of 28 (7%) patients with nonmalignant diseases were positive. The LAI activity disappeared a few months after surgery and remained negative in patients with no evidence of disease as well as in patients with disseminated progressed disease. A change of LAI from negative to positive during the follow up period correlated in some cases with the recurrence of the disease, but was observed also in cases with no clinical evidence of disease.

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Leukocyte adherence inhibition assay in the diagnosis and follow-up of colorectal cancer patients

Abstract

Keywords

ASJC Scopus subject areas

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