Leukocyte-mimicking stem cell delivery via in situ coating of cells with a bioactive hyperbranched polyglycerol

Jae Hyun Jeong; John J. Schmidt; Richie E. Kohman; Andrew T. Zill; Ross J. Devolder; Cartney E. Smith; Mei Hsiu Lai; Artem Shkumatov; Tor W. Jensen; Lawrence G. Schook; Steven C. Zimmerman; Hyunjoon Kong

doi:10.1021/ja400636d

Leukocyte-mimicking stem cell delivery via in situ coating of cells with a bioactive hyperbranched polyglycerol

Jae Hyun Jeong, John J. Schmidt, Richie E. Kohman, Andrew T. Zill, Ross J. Devolder, Cartney E. Smith, Mei Hsiu Lai, Artem Shkumatov, Tor W. Jensen, Lawrence G. Schook, Steven C. Zimmerman, Hyunjoon Kong

Research output: Contribution to journal › Article › peer-review

71 Scopus citations

Abstract

Since stem cells emerged as a new generation of medicine, there are increasing efforts to deliver stem cells to a target tissue via intravascular injection. However, the therapeutic stem cells lack the capacity to detect and adhere to the target tissue. Therefore, this study presents synthesis of a bioactive hyperbranched polyglycerol (HPG) that can noninvasively associate with stem cells and further guide them to target sites, such as inflamed endothelium. The overall process is analogous to the way in which leukocytes are mobilized to the injured endothelium.

Original language	English
Pages (from-to)	8770-8773
Number of pages	4
Journal	Journal of the American Chemical Society
Volume	135
Issue number	24
DOIs	https://doi.org/10.1021/ja400636d
State	Published - 19 Jun 2013
Externally published	Yes

ASJC Scopus subject areas

Catalysis
General Chemistry
Biochemistry
Colloid and Surface Chemistry

Access to Document

10.1021/ja400636d

Cite this

Jeong, J. H., Schmidt, J. J., Kohman, R. E., Zill, A. T., Devolder, R. J., Smith, C. E., Lai, M. H., Shkumatov, A., Jensen, T. W., Schook, L. G., Zimmerman, S. C., & Kong, H. (2013). Leukocyte-mimicking stem cell delivery via in situ coating of cells with a bioactive hyperbranched polyglycerol. Journal of the American Chemical Society, 135(24), 8770-8773. https://doi.org/10.1021/ja400636d

@article{a523a93f5f964379af9973bb4f26ee14,

title = "Leukocyte-mimicking stem cell delivery via in situ coating of cells with a bioactive hyperbranched polyglycerol",

abstract = "Since stem cells emerged as a new generation of medicine, there are increasing efforts to deliver stem cells to a target tissue via intravascular injection. However, the therapeutic stem cells lack the capacity to detect and adhere to the target tissue. Therefore, this study presents synthesis of a bioactive hyperbranched polyglycerol (HPG) that can noninvasively associate with stem cells and further guide them to target sites, such as inflamed endothelium. The overall process is analogous to the way in which leukocytes are mobilized to the injured endothelium.",

author = "Jeong, {Jae Hyun} and Schmidt, {John J.} and Kohman, {Richie E.} and Zill, {Andrew T.} and Devolder, {Ross J.} and Smith, {Cartney E.} and Lai, {Mei Hsiu} and Artem Shkumatov and Jensen, {Tor W.} and Schook, {Lawrence G.} and Zimmerman, {Steven C.} and Hyunjoon Kong",

year = "2013",

month = jun,

day = "19",

doi = "10.1021/ja400636d",

language = "English",

volume = "135",

pages = "8770--8773",

journal = "Journal of the American Chemical Society",

issn = "0002-7863",

publisher = "American Chemical Society",

number = "24",

}

Jeong, JH, Schmidt, JJ, Kohman, RE, Zill, AT, Devolder, RJ, Smith, CE, Lai, MH, Shkumatov, A, Jensen, TW, Schook, LG, Zimmerman, SC & Kong, H 2013, 'Leukocyte-mimicking stem cell delivery via in situ coating of cells with a bioactive hyperbranched polyglycerol', Journal of the American Chemical Society, vol. 135, no. 24, pp. 8770-8773. https://doi.org/10.1021/ja400636d

TY - JOUR

T1 - Leukocyte-mimicking stem cell delivery via in situ coating of cells with a bioactive hyperbranched polyglycerol

AU - Jeong, Jae Hyun

AU - Schmidt, John J.

AU - Kohman, Richie E.

AU - Zill, Andrew T.

AU - Devolder, Ross J.

AU - Smith, Cartney E.

AU - Lai, Mei Hsiu

AU - Shkumatov, Artem

AU - Jensen, Tor W.

AU - Schook, Lawrence G.

AU - Zimmerman, Steven C.

AU - Kong, Hyunjoon

PY - 2013/6/19

Y1 - 2013/6/19

N2 - Since stem cells emerged as a new generation of medicine, there are increasing efforts to deliver stem cells to a target tissue via intravascular injection. However, the therapeutic stem cells lack the capacity to detect and adhere to the target tissue. Therefore, this study presents synthesis of a bioactive hyperbranched polyglycerol (HPG) that can noninvasively associate with stem cells and further guide them to target sites, such as inflamed endothelium. The overall process is analogous to the way in which leukocytes are mobilized to the injured endothelium.

AB - Since stem cells emerged as a new generation of medicine, there are increasing efforts to deliver stem cells to a target tissue via intravascular injection. However, the therapeutic stem cells lack the capacity to detect and adhere to the target tissue. Therefore, this study presents synthesis of a bioactive hyperbranched polyglycerol (HPG) that can noninvasively associate with stem cells and further guide them to target sites, such as inflamed endothelium. The overall process is analogous to the way in which leukocytes are mobilized to the injured endothelium.

UR - http://www.scopus.com/inward/record.url?scp=84879344415&partnerID=8YFLogxK

U2 - 10.1021/ja400636d

DO - 10.1021/ja400636d

M3 - Article

C2 - 23590123

AN - SCOPUS:84879344415

SN - 0002-7863

VL - 135

SP - 8770

EP - 8773

JO - Journal of the American Chemical Society

JF - Journal of the American Chemical Society

IS - 24

ER -

Leukocyte-mimicking stem cell delivery via in situ coating of cells with a bioactive hyperbranched polyglycerol

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this