TY - JOUR
T1 - Leukocytoclastic vasculitis induced by low-dose methotrexate
T2 - In vitro evidence for an immunologic mechanism
AU - Halevy, Sima
AU - Giryes, Hani
AU - Avinoach, Ilana
AU - Livni, Ella
AU - Sukenik, Shaul
PY - 1998/2/27
Y1 - 1998/2/27
N2 - The rare occurrence of methotrexate (MTX)-induced vasculitis has been associated mainly with high or intermediate MTX doses. We report herein a case of cutaneous leukocytoclastic vasculitis (LCV) following treatment with low-dose oral MTX (7.5 mg/week) for rheumatoid arthritis. The histological findings of a cutaneous lesion were consistent with drug-induced vasculitis. The clinical and histological findings, including the temporal relationship between MTX intake and the onset of vasculitis, and the results of withdrawal and rechallenge tests, suggest a causal relationship, and indicate a drug- induced LCV due to MTX. The role of MTX in the induction of the vasculitis was further supported by a positive mast cell degranulation (MCD) test.
AB - The rare occurrence of methotrexate (MTX)-induced vasculitis has been associated mainly with high or intermediate MTX doses. We report herein a case of cutaneous leukocytoclastic vasculitis (LCV) following treatment with low-dose oral MTX (7.5 mg/week) for rheumatoid arthritis. The histological findings of a cutaneous lesion were consistent with drug-induced vasculitis. The clinical and histological findings, including the temporal relationship between MTX intake and the onset of vasculitis, and the results of withdrawal and rechallenge tests, suggest a causal relationship, and indicate a drug- induced LCV due to MTX. The role of MTX in the induction of the vasculitis was further supported by a positive mast cell degranulation (MCD) test.
KW - Leukocytoclastic vasculitis
KW - Mast cell degranulation test
KW - Methotrexate
UR - http://www.scopus.com/inward/record.url?scp=0031907326&partnerID=8YFLogxK
U2 - 10.1016/S0926-9959(97)00114-1
DO - 10.1016/S0926-9959(97)00114-1
M3 - Article
AN - SCOPUS:0031907326
SN - 0926-9959
VL - 10
SP - 81
EP - 85
JO - Journal of the European Academy of Dermatology and Venereology
JF - Journal of the European Academy of Dermatology and Venereology
IS - 1
ER -