Abstract
Objective
To evaluate the influence of intergenerational factors on low birthweight (LBW) and preeclampsia.
Study Design
A retrospective population-based study was conducted. Perinatal information of 2314 triads of mothers, daughters giving births in a tertiary medical center between the years 1991-2012 and grandchildren was matched into the same database. Multivariate logistic regression analysis and generalized estimating equation cluster analysis was used to study the association between LBW and preeclampsia in both generations while controlling for confounders, and for clusters of families in the database.
Results
A total of 1493 mothers to, 1619 daughters, and 2314 grandchildren were included. LBW in mothers was found as a significant predictor for LBW in offspring (OR=1.7, 95% CI 1.1-2.6, P=0.012; Table) adjusted for maternal age, placental pathology, preeclampsia, parity. Likewise, preeclampsia was also noted as a significant intergenerational factor, adjusted for maternal age, and parity, in another model (adjusted OR= 2.9, 95% CI 1.5-5.7, P=0.002; Table).
Conclusion
Maternal low birthweight and preeclampsia are both independent risk factors for recurrence at the next generation.
To evaluate the influence of intergenerational factors on low birthweight (LBW) and preeclampsia.
Study Design
A retrospective population-based study was conducted. Perinatal information of 2314 triads of mothers, daughters giving births in a tertiary medical center between the years 1991-2012 and grandchildren was matched into the same database. Multivariate logistic regression analysis and generalized estimating equation cluster analysis was used to study the association between LBW and preeclampsia in both generations while controlling for confounders, and for clusters of families in the database.
Results
A total of 1493 mothers to, 1619 daughters, and 2314 grandchildren were included. LBW in mothers was found as a significant predictor for LBW in offspring (OR=1.7, 95% CI 1.1-2.6, P=0.012; Table) adjusted for maternal age, placental pathology, preeclampsia, parity. Likewise, preeclampsia was also noted as a significant intergenerational factor, adjusted for maternal age, and parity, in another model (adjusted OR= 2.9, 95% CI 1.5-5.7, P=0.002; Table).
Conclusion
Maternal low birthweight and preeclampsia are both independent risk factors for recurrence at the next generation.
| Original language | English |
|---|---|
| Pages (from-to) | S34-S34 |
| Journal | American Journal of Obstetrics and Gynecology |
| Volume | 212 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 2015 |