Limitations of the standard agglutination test for detecting patients with brucella melitensis bacteremia

Ari A. Shemesh; Pablo Yagupsky

doi:10.1089/vbz.2011.0704

Limitations of the standard agglutination test for detecting patients with brucella melitensis bacteremia

Ari A. Shemesh, Pablo Yagupsky

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

The sensitivity of the standard agglutination test (SAT) for detecting brucellosis was determined in 264 Israeli patients from whom a positive blood culture for Brucella melitensis and serology were obtained within±1 week. A SAT titer ≥1:160 had a diagnostic sensitivity of 91.7%, whereas raising the cutoff to ≥1:320, as recommended to decrease false-positive rates in endemic areas, reduced the sensitivity to 82.6%. Physicians working in regions endemic for brucellosis should be aware of the limitations of the SAT for detecting patients with the disease.

Original language	English
Pages (from-to)	1599-1601
Number of pages	3
Journal	Vector-Borne and Zoonotic Diseases
Volume	11
Issue number	12
DOIs	https://doi.org/10.1089/vbz.2011.0704
State	Published - 1 Dec 2011

Keywords

Bacteremia
Human brucellosis
Sensitivity
Standard agglutination test

ASJC Scopus subject areas

Microbiology
Infectious Diseases
Virology

Access to Document

10.1089/vbz.2011.0704

Cite this

@article{d89ab71603834cc8a7e3d8918818de46,

title = "Limitations of the standard agglutination test for detecting patients with brucella melitensis bacteremia",

abstract = "The sensitivity of the standard agglutination test (SAT) for detecting brucellosis was determined in 264 Israeli patients from whom a positive blood culture for Brucella melitensis and serology were obtained within±1 week. A SAT titer ≥1:160 had a diagnostic sensitivity of 91.7%, whereas raising the cutoff to ≥1:320, as recommended to decrease false-positive rates in endemic areas, reduced the sensitivity to 82.6%. Physicians working in regions endemic for brucellosis should be aware of the limitations of the SAT for detecting patients with the disease.",

keywords = "Bacteremia, Human brucellosis, Sensitivity, Standard agglutination test",

author = "Shemesh, {Ari A.} and Pablo Yagupsky",

year = "2011",

month = dec,

day = "1",

doi = "10.1089/vbz.2011.0704",

language = "English",

volume = "11",

pages = "1599--1601",

journal = "Vector-Borne and Zoonotic Diseases",

issn = "1530-3667",

publisher = "Mary Ann Liebert Inc.",

number = "12",

}

TY - JOUR

T1 - Limitations of the standard agglutination test for detecting patients with brucella melitensis bacteremia

AU - Shemesh, Ari A.

AU - Yagupsky, Pablo

PY - 2011/12/1

Y1 - 2011/12/1

N2 - The sensitivity of the standard agglutination test (SAT) for detecting brucellosis was determined in 264 Israeli patients from whom a positive blood culture for Brucella melitensis and serology were obtained within±1 week. A SAT titer ≥1:160 had a diagnostic sensitivity of 91.7%, whereas raising the cutoff to ≥1:320, as recommended to decrease false-positive rates in endemic areas, reduced the sensitivity to 82.6%. Physicians working in regions endemic for brucellosis should be aware of the limitations of the SAT for detecting patients with the disease.

AB - The sensitivity of the standard agglutination test (SAT) for detecting brucellosis was determined in 264 Israeli patients from whom a positive blood culture for Brucella melitensis and serology were obtained within±1 week. A SAT titer ≥1:160 had a diagnostic sensitivity of 91.7%, whereas raising the cutoff to ≥1:320, as recommended to decrease false-positive rates in endemic areas, reduced the sensitivity to 82.6%. Physicians working in regions endemic for brucellosis should be aware of the limitations of the SAT for detecting patients with the disease.

KW - Bacteremia

KW - Human brucellosis

KW - Sensitivity

KW - Standard agglutination test

UR - http://www.scopus.com/inward/record.url?scp=83455221019&partnerID=8YFLogxK

U2 - 10.1089/vbz.2011.0704

DO - 10.1089/vbz.2011.0704

M3 - Article

C2 - 21919731

AN - SCOPUS:83455221019

SN - 1530-3667

VL - 11

SP - 1599

EP - 1601

JO - Vector-Borne and Zoonotic Diseases

JF - Vector-Borne and Zoonotic Diseases

IS - 12

ER -

Limitations of the standard agglutination test for detecting patients with brucella melitensis bacteremia

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this