Limitations of the standard agglutination test for detecting patients with brucella melitensis bacteremia

Ari A. Shemesh; Pablo Yagupsky

doi:10.1089/vbz.2011.0704

Limitations of the standard agglutination test for detecting patients with brucella melitensis bacteremia

Ari A. Shemesh, Pablo Yagupsky

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

The sensitivity of the standard agglutination test (SAT) for detecting brucellosis was determined in 264 Israeli patients from whom a positive blood culture for Brucella melitensis and serology were obtained within±1 week. A SAT titer ≥1:160 had a diagnostic sensitivity of 91.7%, whereas raising the cutoff to ≥1:320, as recommended to decrease false-positive rates in endemic areas, reduced the sensitivity to 82.6%. Physicians working in regions endemic for brucellosis should be aware of the limitations of the SAT for detecting patients with the disease.

Original language	English
Pages (from-to)	1599-1601
Number of pages	3
Journal	Vector-Borne and Zoonotic Diseases
Volume	11
Issue number	12
DOIs	https://doi.org/10.1089/vbz.2011.0704
State	Published - 1 Dec 2011

Keywords

Bacteremia
Human brucellosis
Sensitivity
Standard agglutination test

ASJC Scopus subject areas

Microbiology
Infectious Diseases
Virology

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10.1089/vbz.2011.0704

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title = "Limitations of the standard agglutination test for detecting patients with brucella melitensis bacteremia",

abstract = "The sensitivity of the standard agglutination test (SAT) for detecting brucellosis was determined in 264 Israeli patients from whom a positive blood culture for Brucella melitensis and serology were obtained within±1 week. A SAT titer ≥1:160 had a diagnostic sensitivity of 91.7\%, whereas raising the cutoff to ≥1:320, as recommended to decrease false-positive rates in endemic areas, reduced the sensitivity to 82.6\%. Physicians working in regions endemic for brucellosis should be aware of the limitations of the SAT for detecting patients with the disease.",

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N2 - The sensitivity of the standard agglutination test (SAT) for detecting brucellosis was determined in 264 Israeli patients from whom a positive blood culture for Brucella melitensis and serology were obtained within±1 week. A SAT titer ≥1:160 had a diagnostic sensitivity of 91.7%, whereas raising the cutoff to ≥1:320, as recommended to decrease false-positive rates in endemic areas, reduced the sensitivity to 82.6%. Physicians working in regions endemic for brucellosis should be aware of the limitations of the SAT for detecting patients with the disease.

AB - The sensitivity of the standard agglutination test (SAT) for detecting brucellosis was determined in 264 Israeli patients from whom a positive blood culture for Brucella melitensis and serology were obtained within±1 week. A SAT titer ≥1:160 had a diagnostic sensitivity of 91.7%, whereas raising the cutoff to ≥1:320, as recommended to decrease false-positive rates in endemic areas, reduced the sensitivity to 82.6%. Physicians working in regions endemic for brucellosis should be aware of the limitations of the SAT for detecting patients with the disease.

KW - Bacteremia

KW - Human brucellosis

KW - Sensitivity

KW - Standard agglutination test

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JF - Vector-Borne and Zoonotic Diseases

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ER -

Limitations of the standard agglutination test for detecting patients with brucella melitensis bacteremia

Abstract

Keywords

ASJC Scopus subject areas

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