Linezolid-Induced Lactic Acidosis Sets Stage for Surgery to Rule Out Mesenteric Ischemia: A Case Report

Kiran Belani, Akiva Leibowitz, Somnath Bose

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

An 81-year-old woman with extensive peripheral vascular and coronary artery disease was admitted to the intensive care unit with a deep heel abscess and urinary tract infection. When cultures from the heel ulcer yielded vancomycin-resistant enterococci, she was started on the antibiotic linezolid. After several days of intravenous linezolid therapy, she developed severe lactic acidosis (pH 6.89) and elevation of pancreatic enzymes. An emergent exploratory laparotomy was performed to rule out mesenteric ischemia. Findings from the laparotomy were negative, and after elimination of other differential diagnoses, the metabolic acidosis was ultimately attributed to linezolid. Acidosis resolved after discontinuation of linezolid.

Original languageEnglish
Pages (from-to)93-95
Number of pages3
JournalA&A practice
Volume11
Issue number4
DOIs
StatePublished - 15 Aug 2018

ASJC Scopus subject areas

  • General Medicine

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