A number of candidate genes have recently been associated with human personality and temperament traits especially the dopamine D4 receptor and the serotonin promoter region polymorphism. Recently, the first linkage study of personality traits 1 examined 758 pairs of siblings in 177 nuclear families of alcoholics detected significant linkage between the trait Harm Avoidance, a measure of anxiety proneness, and a locus on chromosome 8p21-23 that explained 38% of the trait variance. Cloninger has proposed that genes contributing to the determination of personality dimensions might also confer risk for major mental illness. This hypothesis prompted us to examine three chromosomal regions linked to major psychoses for loci also relevant to personality traits (chromosome 1q22, 8p21-22 and 22q12) using microsatellite markers (D1S1677, D1S1679, D1S1653; D8S133. D8S1106, D8S136; D22S278, D22S277, D22S685, D22S1142). We have completed genotyping approximately 205 sib pairs (without parents DNA) and 210 sib pairs including parents DNA from subjects recruited for our studies of normal personality using the TPQ self-report questionnaire. Preliminary analysis of part of the data set indicated a susceptibility locus for TPQ Harm Avoidance on chromosome 22q. The completed genotyping and linkage analysis will be presented for all three chromosomal regions.
|Number of pages
|American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
|Published - 8 Oct 2001
ASJC Scopus subject areas
- Psychiatry and Mental health
- Cellular and Molecular Neuroscience