Lipomatous tumors of the oral mucosa: Histomorphological, histochemical and immunohistochemical features

Irit Allon, Sara Aballo, Dan Dayan, Marilena Vered

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


We conducted a comprehensive study of all lipomatous tumors of the oral mucosa (1996-2008) accessioned at the Department of Oral Pathology, Tel Aviv University, collected demographic data and analyzed multiple histomorphological features. Furthermore, we examined the immunostaining of aP2 (adipocyte lipid binding protein) and the polarization colors of picrosirius red (PSR)-stained collagen fibers in order to test their potential in differentiating between benign and malignant tumors. All cases were immunohistochemically stained with aP2 antibody; only tumors with considerable collagenous stroma were selected for the PSR staining. A total of 77 tumors were included in the study, 91% benign and 9% malignant. Fibrolipoma (37.7%) and lipoma (36.4%) were the most frequent tumors. Atypical lipomatous tumor (ALT) was the only type of malignancy. The most common location for the benign tumors was the buccal mucosa and for ALT, the tongue. Histomorphological features characteristic of malignant tumors were occasionally present also in the benign entities. Expression of aP2 was similar in all tumors, while the polarization colors of the PSR-stained collagen fibers differed significantly between ALT and benign tumors (p<0.05). Benign and malignant tumors occasionally show overlapping histomorphological features that require a meticulous examination. PSR staining with polarization microscopy could aid in differentiating malignant from benign tumors in equivocal cases.

Original languageEnglish
Pages (from-to)803-809
Number of pages7
JournalActa Histochemica
Issue number8
StatePublished - 1 Dec 2011
Externally publishedYes


  • AP2
  • Human
  • Lipomatous tumors
  • Oral mucosa
  • Picrosirius red
  • Polarizing microscopy

ASJC Scopus subject areas

  • Histology
  • Cell Biology


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