Lipopolysaccharide-induced production of tumor necrosis factor activity in rats with and without risk factors for stroke

John M. Hallenbeck; Andrew J. Dutka; Stefanie N. Vogel; Eliahu Heldman; David A. Doron; Giora Feuerstein

doi:10.1016/0006-8993(91)91083-D

Lipopolysaccharide-induced production of tumor necrosis factor activity in rats with and without risk factors for stroke

John M. Hallenbeck, Andrew J. Dutka, Stefanie N. Vogel, Eliahu Heldman, David A. Doron, Giora Feuerstein

Research output: Contribution to journal › Article › peer-review

52 Scopus citations

Abstract

Rats produced more TNF activity in cerebrospinal fluid (CSF) than in blood after intracerebroventricular (i.c.v.) injection of lipopolysaccharide (LPS). After intravenous (i.v.) LPS, blood TNF levels exceeded CSF levels. Thus, brain cells appear to produce TNF in response to LPS. Rats with the stroke-risk factors hypertension or combined hypertension and genetic stroke-proneness produce more TNF in response to a provocative dose of LPS i.v. than control animals free of these risk factors. The possible relevance to stroke vulnerability is discussed.

Original language	English
Pages (from-to)	115-120
Number of pages	6
Journal	Brain Research
Volume	541
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(91)91083-D
State	Published - 8 Feb 1991
Externally published	Yes

Keywords

Cerebrospinal fluid
Macrophage
Monocyte
Rat
Stroke
Stroke-risk factor
Tumor necrosis factor-α

ASJC Scopus subject areas

Neuroscience (all)
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/0006-8993(91)91083-D

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title = "Lipopolysaccharide-induced production of tumor necrosis factor activity in rats with and without risk factors for stroke",

abstract = "Rats produced more TNF activity in cerebrospinal fluid (CSF) than in blood after intracerebroventricular (i.c.v.) injection of lipopolysaccharide (LPS). After intravenous (i.v.) LPS, blood TNF levels exceeded CSF levels. Thus, brain cells appear to produce TNF in response to LPS. Rats with the stroke-risk factors hypertension or combined hypertension and genetic stroke-proneness produce more TNF in response to a provocative dose of LPS i.v. than control animals free of these risk factors. The possible relevance to stroke vulnerability is discussed.",

keywords = "Cerebrospinal fluid, Macrophage, Monocyte, Rat, Stroke, Stroke-risk factor, Tumor necrosis factor-α",

author = "Hallenbeck, {John M.} and Dutka, {Andrew J.} and Vogel, {Stefanie N.} and Eliahu Heldman and Doron, {David A.} and Giora Feuerstein",

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T1 - Lipopolysaccharide-induced production of tumor necrosis factor activity in rats with and without risk factors for stroke

AU - Hallenbeck, John M.

AU - Dutka, Andrew J.

AU - Vogel, Stefanie N.

AU - Heldman, Eliahu

AU - Doron, David A.

AU - Feuerstein, Giora

PY - 1991/2/8

Y1 - 1991/2/8

N2 - Rats produced more TNF activity in cerebrospinal fluid (CSF) than in blood after intracerebroventricular (i.c.v.) injection of lipopolysaccharide (LPS). After intravenous (i.v.) LPS, blood TNF levels exceeded CSF levels. Thus, brain cells appear to produce TNF in response to LPS. Rats with the stroke-risk factors hypertension or combined hypertension and genetic stroke-proneness produce more TNF in response to a provocative dose of LPS i.v. than control animals free of these risk factors. The possible relevance to stroke vulnerability is discussed.

AB - Rats produced more TNF activity in cerebrospinal fluid (CSF) than in blood after intracerebroventricular (i.c.v.) injection of lipopolysaccharide (LPS). After intravenous (i.v.) LPS, blood TNF levels exceeded CSF levels. Thus, brain cells appear to produce TNF in response to LPS. Rats with the stroke-risk factors hypertension or combined hypertension and genetic stroke-proneness produce more TNF in response to a provocative dose of LPS i.v. than control animals free of these risk factors. The possible relevance to stroke vulnerability is discussed.

KW - Cerebrospinal fluid

KW - Macrophage

KW - Monocyte

KW - Rat

KW - Stroke

KW - Stroke-risk factor

KW - Tumor necrosis factor-α

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JO - Brain Research

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Lipopolysaccharide-induced production of tumor necrosis factor activity in rats with and without risk factors for stroke

Abstract

Keywords

ASJC Scopus subject areas

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