Lipopolysaccharide-induced production of tumor necrosis factor activity in rats with and without risk factors for stroke

John M. Hallenbeck, Andrew J. Dutka, Stefanie N. Vogel, Eliahu Heldman, David A. Doron, Giora Feuerstein

Research output: Contribution to journalArticlepeer-review

52 Scopus citations

Abstract

Rats produced more TNF activity in cerebrospinal fluid (CSF) than in blood after intracerebroventricular (i.c.v.) injection of lipopolysaccharide (LPS). After intravenous (i.v.) LPS, blood TNF levels exceeded CSF levels. Thus, brain cells appear to produce TNF in response to LPS. Rats with the stroke-risk factors hypertension or combined hypertension and genetic stroke-proneness produce more TNF in response to a provocative dose of LPS i.v. than control animals free of these risk factors. The possible relevance to stroke vulnerability is discussed.

Original languageEnglish
Pages (from-to)115-120
Number of pages6
JournalBrain Research
Volume541
Issue number1
DOIs
StatePublished - 8 Feb 1991
Externally publishedYes

Keywords

  • Cerebrospinal fluid
  • Macrophage
  • Monocyte
  • Rat
  • Stroke
  • Stroke-risk factor
  • Tumor necrosis factor-α

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