Lipopolysaccharides of a Campylobacter coli isolate from a patient with Guillain-Barre syndrome display ganglioside mimicry

Marina Bersudsky, Philip Rosenberg, Bernard Rudensky, Itzhak Wirguin

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

Campylobacter coli was isolated from a patient with severe, axonal type Guillain-Barre syndrome (GBS). The patient's serum was tested by ELISA for glycolipid antibodies and showed a high titer of IgG antibodies to asialo-GM1 (GA1) and GD3. Campylobacter coli lipopolysaccharide (LPS) was extracted and analyzed by ELISA, immunoblot binding and blocking studies, and found to avidly bind cholera toxin and peanut agglutinin. The LPS from the patient's isolate also induced anti-GA1 antibodies in a rat model. These findings suggest that the LPS from this bacterial isolate contains a ganglioside-like epitope, which most likely resembles GA1. Thus, it appears that ganglioside cross-reactivity is not unique to Campylobacter jejuni and seems to occur in all bacterial isolates from GBS cases so far analyzed. Copyright (C) 2000 Elsevier Science B.V.

Original languageEnglish
Pages (from-to)182-186
Number of pages5
JournalNeuromuscular Disorders
Volume10
Issue number3
DOIs
StatePublished - 1 Mar 2000
Externally publishedYes

Keywords

  • Campylobacter coli
  • Ganglioside antibodies
  • Guillain-Barre syndrome
  • Lipopolysaccharides (LPS)
  • Molecular mimicry

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Neurology
  • Clinical Neurology
  • Genetics(clinical)

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