Liposarcoma of the tongue: Clinico-pathologic correlations of a possible underdiagnosed entity

Irit Allon, Marilena Vered, Dan Dayan

Research output: Contribution to journalReview articlepeer-review

18 Scopus citations


Liposarcoma (LS), one of the most common malignant tumors, is considered as a rarity in the oral cavity, the tongue being the most frequent site for its occurrence. The purpose of the present study was to review and analyze the clinico-pathologic correlations of 32 cases of LS of the tongue, including four new cases from the files of our department. A total of 32 cases of LS of the tongue were collected, 29 from a MEDLINE search of the English language literature (1966-2004). Since the histopathologic features of one of the four new cases have been presented previously, this case was counted only once. LS of the tongue is a tumor of adult and old age, with a mean age of approximately 62 years and a peak incidence in the seventh and eighth decades. Clinically, it is a long-standing tumor that commonly presents as a solitary nodular mass, but can also present as a multi-nodular lesion. The most common histopathologic type is that of atypical lipomatous tumor (ALT)/well-differentiated LS (75%). LS can be easily misdiagnosed with both benign and malignant lipomatous and non-lipomatous tumors. LS of the tongue was commonly treated by local excision, however, there were cases of (multiple) recurrences and dedifferentiation. When a lipomatous lesion is encountered in the oral cavity, and especially in the tongue, LS should certainly be among the lesions that top the list of differential diagnosis. The follow-up must be on a long-term basis since this tumor can recur years after initial surgical treatment and can also undergo dedifferentiation.

Original languageEnglish
Pages (from-to)657-665
Number of pages9
JournalOral Oncology
Issue number7
StatePublished - 1 Aug 2005
Externally publishedYes


  • Atypical lipomatous tumor
  • Liposarcoma
  • Misdiagnosis
  • Tongue
  • Well-differentiated liposarcoma

ASJC Scopus subject areas

  • Oral Surgery
  • Oncology
  • Cancer Research


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