Lii-Nao countertransport and Li leak in erythrocytes are differentially affected by membrane enrichment with cholesteryl hemisuccinate

Rachel Levy; Dana Hevroni; Z. Ioav Cabantchik; Avinoam Livne

doi:10.1016/0005-2736(86)90127-6

Li_i-Na_o countertransport and Li leak in erythrocytes are differentially affected by membrane enrichment with cholesteryl hemisuccinate

Rachel Levy, Dana Hevroni, Z. Ioav Cabantchik, Avinoam Livne

Department of Clinical Biochemistry and Pharmacology

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Enrichment of erythrocytes with cholesteryl hemisuccinate caused a marked reduction in Li leak but did not change kinetic and thermodynamic properties of Li_i-Na_o countertransport of either normotensive persons or patients with essential hypertension. As cholesteryl hemisuccinate was shown to affect the membrane similarly to cholesterol, it is likely that the unique thermodynamic properties of erythrocyte Li_i-Na_o countertransport in essential hypertension are not caused by changes in cholesterol.

Original language	English
Pages (from-to)	325-328
Number of pages	4
Journal	Biochimica et Biophysica Acta - Biomembranes
Volume	854
Issue number	2
DOIs	https://doi.org/10.1016/0005-2736(86)90127-6
State	Published - 29 Jan 1986

Keywords

Cholesteryl hemisuccinate
Erythrocyte membrane
Hypertension
Na-Li countertransport

ASJC Scopus subject areas

Biophysics
Biochemistry
Cell Biology

Access to Document

10.1016/0005-2736(86)90127-6

Cite this

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abstract = "Enrichment of erythrocytes with cholesteryl hemisuccinate caused a marked reduction in Li leak but did not change kinetic and thermodynamic properties of Lii-Nao countertransport of either normotensive persons or patients with essential hypertension. As cholesteryl hemisuccinate was shown to affect the membrane similarly to cholesterol, it is likely that the unique thermodynamic properties of erythrocyte Lii-Nao countertransport in essential hypertension are not caused by changes in cholesterol.",

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AU - Levy, Rachel

AU - Hevroni, Dana

AU - Cabantchik, Z. Ioav

AU - Livne, Avinoam

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N2 - Enrichment of erythrocytes with cholesteryl hemisuccinate caused a marked reduction in Li leak but did not change kinetic and thermodynamic properties of Lii-Nao countertransport of either normotensive persons or patients with essential hypertension. As cholesteryl hemisuccinate was shown to affect the membrane similarly to cholesterol, it is likely that the unique thermodynamic properties of erythrocyte Lii-Nao countertransport in essential hypertension are not caused by changes in cholesterol.

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KW - Cholesteryl hemisuccinate

KW - Erythrocyte membrane

KW - Hypertension

KW - Na-Li countertransport

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