Lithium amelioration ofreserpine-induced hypoactivity in rats

B. Lerer; R. P. Ebstein; A. Felix; R. H. Belmaker

doi:10.1159/000468460

Lithium amelioration ofreserpine-induced hypoactivity in rats

B. Lerer, R. P. Ebstein, A. Felix, R. H. Belmaker

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Oral lithium pretreatment of rats for 19 days significantly prevented the behavioral immobility induced by moderate doses of reserpine. High dose of reserpine overwhelmed the lithium effect. Development of a simple and specific behavioral test of lithium-like activity in animals could allow for screening and possible development of new lithium-like compounds.

Original language	English
Pages (from-to)	338-343
Number of pages	6
Journal	International Pharmacopsychiatry
Volume	15
Issue number	6
DOIs	https://doi.org/10.1159/000468460
State	Published - 1 Jan 1980
Externally published	Yes

ASJC Scopus subject areas

General Medicine

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10.1159/000468460

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title = "Lithium amelioration ofreserpine-induced hypoactivity in rats",

abstract = "Oral lithium pretreatment of rats for 19 days significantly prevented the behavioral immobility induced by moderate doses of reserpine. High dose of reserpine overwhelmed the lithium effect. Development of a simple and specific behavioral test of lithium-like activity in animals could allow for screening and possible development of new lithium-like compounds.",

author = "B. Lerer and Ebstein, {R. P.} and A. Felix and Belmaker, {R. H.}",

year = "1980",

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T1 - Lithium amelioration ofreserpine-induced hypoactivity in rats

AU - Lerer, B.

AU - Ebstein, R. P.

AU - Felix, A.

AU - Belmaker, R. H.

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Y1 - 1980/1/1

N2 - Oral lithium pretreatment of rats for 19 days significantly prevented the behavioral immobility induced by moderate doses of reserpine. High dose of reserpine overwhelmed the lithium effect. Development of a simple and specific behavioral test of lithium-like activity in animals could allow for screening and possible development of new lithium-like compounds.

AB - Oral lithium pretreatment of rats for 19 days significantly prevented the behavioral immobility induced by moderate doses of reserpine. High dose of reserpine overwhelmed the lithium effect. Development of a simple and specific behavioral test of lithium-like activity in animals could allow for screening and possible development of new lithium-like compounds.

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U2 - 10.1159/000468460

DO - 10.1159/000468460

M3 - Article

AN - SCOPUS:0019231063

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JO - International Pharmacopsychiatry

JF - International Pharmacopsychiatry

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ER -

Lithium amelioration ofreserpine-induced hypoactivity in rats

Abstract

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