Live cell microRNA imaging using cascade hybridization reaction

Zoya Cheglakov, Timothy M. Cronin, Chuan He, Yossi Weizmann

Research output: Contribution to journalArticlepeer-review

170 Scopus citations

Abstract

Recent advances in RNA research have posed new directives in biology and chemistry to uncover the complex roles of ribonucleic acids in cellular processes. Innovative techniques to visualize native RNAs, particularly, short, low-abundance RNAs in live cells, can dramatically impact current research on the roles of RNAs in biology. Herein, we report a novel method for real-time, microRNA imaging inside live cells based on programmable oligonucleotide probes, which self-assemble through the Cascade Hybridization Reaction (CHR).

Original languageEnglish
Pages (from-to)6116-6119
Number of pages4
JournalJournal of the American Chemical Society
Volume137
Issue number19
DOIs
StatePublished - 20 May 2015
Externally publishedYes

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