TY - JOUR
T1 - Liver cirrhosis in elderly patients
T2 - clinical characteristics, complications, and survival—analyses from a large retrospective study
AU - Abu-Freha, Naim
AU - Estis-Deaton, Asia
AU - Aasla, Muhammad
AU - Etzion, Ohad
AU - Philip, Aerin
AU - Yardeni, David
AU - Abo Abed, Muhammad
AU - Abu Tailakh, Muhammad
N1 - Publisher Copyright:
© 2022, The Author(s), under exclusive licence to Springer Nature Switzerland AG.
PY - 2022/6/7
Y1 - 2022/6/7
N2 - Background: Liver cirrhosis (LC) is a common disease diagnosed in all ages. With the increasing population age, LC is noticeable more in the clinics. Aim: To distinguish the clinical characteristics, complications, and survival of patients with liver cirrhosis. Methods: A retrospective study enrolled patients diagnosed with liver cirrhosis at Soroka University Medical Center. Patients with cirrhosis diagnosed at an age older than 65 years (group 1) were compared with patients diagnosed at an age younger than 65 years (group 2). Results: We included 1046 patients; 411 (39.3%) in group 1 and 635 (60.7%) in group 2. Fatty liver and cryptogenic liver disease were found to cause cirrhosis at a significantly higher rate in the elderly (23.4% vs. 13.9%, p < 0.001, 15.3% vs. 6.3%, p < 0.001, respectively). A higher rate of non-hepatocellular carcinoma cancers and mortality (17.5% vs. 9.1%, p < 0.001, 76.6% vs. 57%, respectively) was found among cirrhotic elderly patients, but a lower rate of oesophageal varices (47.7% vs. 60.1%, p = 0.002). Twenty-year follow-up Kaplan–Meier survival analysis for mortality estimated poor survival in the elderly (log-rank p < 0.001). The adjusted Cox proportional hazards regression model showed an association of age > 65 with an all-cause mortality hazard ratio of 2.26 (95% CI 1.89–2.69). Conclusion: Higher rates of fatty liver, cryptogenic cirrhosis, non-HCC cancers, and mortality were found among patients diagnosed with cirrhosis in the elderly.
AB - Background: Liver cirrhosis (LC) is a common disease diagnosed in all ages. With the increasing population age, LC is noticeable more in the clinics. Aim: To distinguish the clinical characteristics, complications, and survival of patients with liver cirrhosis. Methods: A retrospective study enrolled patients diagnosed with liver cirrhosis at Soroka University Medical Center. Patients with cirrhosis diagnosed at an age older than 65 years (group 1) were compared with patients diagnosed at an age younger than 65 years (group 2). Results: We included 1046 patients; 411 (39.3%) in group 1 and 635 (60.7%) in group 2. Fatty liver and cryptogenic liver disease were found to cause cirrhosis at a significantly higher rate in the elderly (23.4% vs. 13.9%, p < 0.001, 15.3% vs. 6.3%, p < 0.001, respectively). A higher rate of non-hepatocellular carcinoma cancers and mortality (17.5% vs. 9.1%, p < 0.001, 76.6% vs. 57%, respectively) was found among cirrhotic elderly patients, but a lower rate of oesophageal varices (47.7% vs. 60.1%, p = 0.002). Twenty-year follow-up Kaplan–Meier survival analysis for mortality estimated poor survival in the elderly (log-rank p < 0.001). The adjusted Cox proportional hazards regression model showed an association of age > 65 with an all-cause mortality hazard ratio of 2.26 (95% CI 1.89–2.69). Conclusion: Higher rates of fatty liver, cryptogenic cirrhosis, non-HCC cancers, and mortality were found among patients diagnosed with cirrhosis in the elderly.
KW - Complications
KW - Elderly
KW - Fatty liver
KW - Mortality
UR - http://www.scopus.com/inward/record.url?scp=85131537742&partnerID=8YFLogxK
U2 - 10.1007/s40520-022-02152-6
DO - 10.1007/s40520-022-02152-6
M3 - Article
C2 - 35670959
SN - 1594-0667
VL - 34
SP - 2217
EP - 2223
JO - Aging Clinical and Experimental Research
JF - Aging Clinical and Experimental Research
IS - 9
ER -