Liver function and protein binding in camels

Z. Ben-Zvi; C. Van Creveld; R. Yagil

doi:10.1016/0300-9629(89)90049-2

Liver function and protein binding in camels

Z. Ben-Zvi, C. Van Creveld, R. Yagil

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Abstract

1. 1. Dehydration of camels for 10 days resulted in reduction of liver functions, expressed in longer half life and reduced clearance of bromosulfophthalein (BSP), elevated AST (ALT levels were below the limit of detection of the method) and reduced serum albumin concentrations. 2. 2. Binding of BSP to camel serum proteins by gel permeation chromatography and by equilibrium dialysis showed very strong binding. 3. 3. Binding parameters of various drugs to camels' serum by equilibrium dialysis showed close similarities both qualitatively and quantitatively to those of humans. 4. 4. Albumin seems to be the major serum binding protein of BSP.

Original language	English
Pages (from-to)	349-352
Number of pages	4
Journal	Comparative Biochemistry and Physiology -- Part A: Physiology
Volume	93
Issue number	2
DOIs	https://doi.org/10.1016/0300-9629(89)90049-2
State	Published - 1 Jan 1989

ASJC Scopus subject areas

Physiology

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title = "Liver function and protein binding in camels",

abstract = "1. 1. Dehydration of camels for 10 days resulted in reduction of liver functions, expressed in longer half life and reduced clearance of bromosulfophthalein (BSP), elevated AST (ALT levels were below the limit of detection of the method) and reduced serum albumin concentrations. 2. 2. Binding of BSP to camel serum proteins by gel permeation chromatography and by equilibrium dialysis showed very strong binding. 3. 3. Binding parameters of various drugs to camels' serum by equilibrium dialysis showed close similarities both qualitatively and quantitatively to those of humans. 4. 4. Albumin seems to be the major serum binding protein of BSP.",

author = "Z. Ben-Zvi and {Van Creveld}, C. and R. Yagil",

year = "1989",

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T1 - Liver function and protein binding in camels

AU - Ben-Zvi, Z.

AU - Van Creveld, C.

AU - Yagil, R.

PY - 1989/1/1

Y1 - 1989/1/1

N2 - 1. 1. Dehydration of camels for 10 days resulted in reduction of liver functions, expressed in longer half life and reduced clearance of bromosulfophthalein (BSP), elevated AST (ALT levels were below the limit of detection of the method) and reduced serum albumin concentrations. 2. 2. Binding of BSP to camel serum proteins by gel permeation chromatography and by equilibrium dialysis showed very strong binding. 3. 3. Binding parameters of various drugs to camels' serum by equilibrium dialysis showed close similarities both qualitatively and quantitatively to those of humans. 4. 4. Albumin seems to be the major serum binding protein of BSP.

AB - 1. 1. Dehydration of camels for 10 days resulted in reduction of liver functions, expressed in longer half life and reduced clearance of bromosulfophthalein (BSP), elevated AST (ALT levels were below the limit of detection of the method) and reduced serum albumin concentrations. 2. 2. Binding of BSP to camel serum proteins by gel permeation chromatography and by equilibrium dialysis showed very strong binding. 3. 3. Binding parameters of various drugs to camels' serum by equilibrium dialysis showed close similarities both qualitatively and quantitatively to those of humans. 4. 4. Albumin seems to be the major serum binding protein of BSP.

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JO - Comparative Biochemistry and Physiology -- Part A: Physiology

JF - Comparative Biochemistry and Physiology -- Part A: Physiology

IS - 2

ER -

Liver function and protein binding in camels

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