Localization of two X-linked mental retardation (XLMR) genes to Xp: MRX37 gene at Xp22.31-p22.32 and a putative MRX gene on Xp22.11-p22.2

Shirly Bar-David, Israela Lerer, Chava Kimchi Sarfaty, Zully Gelman Kohan, Vardiella Meiner, Joel Zlotogora, Dvorah Abeliovich

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

MRX genes of 2 families with X-linked mental retardation (XLMR) were localized by linkage analysis. In family A, the gene was mapped to Xp22.31- p22.32, with significant LOD scores to various Xp22 markers within a distance of 6 Mb between DXS1223 and DXS1224. The MRX gene of this family was designated MRX37. In a mentally retarded female who is a carrier of the MRX37 gene, a random pattern of X inactivation was demonstrated. In family B, a positive LOD score, although not significant (<+2), was found with the marker DXS1202 at Xp22.11-p22.2.

Original languageEnglish
Pages (from-to)83-88
Number of pages6
JournalAmerican Journal of Medical Genetics
Volume64
Issue number1
DOIs
StatePublished - 12 Jul 1996
Externally publishedYes

Keywords

  • Fra(X)B
  • MRX genes
  • MRX37
  • X inactivation
  • Xp22

ASJC Scopus subject areas

  • Genetics(clinical)

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