Localization of two X-linked mental retardation (XLMR) genes to Xp: MRX37 gene at Xp22.31-p22.32 and a putative MRX gene on Xp22.11-p22.2

Shirly Bar-David; Israela Lerer; Chava Kimchi Sarfaty; Zully Gelman Kohan; Vardiella Meiner; Joel Zlotogora; Dvorah Abeliovich

doi:10.1002/(SICI)1096-8628(19960712)64:1<83::AID-AJMG15>3.0.CO;2-O

Localization of two X-linked mental retardation (XLMR) genes to Xp: MRX37 gene at Xp22.31-p22.32 and a putative MRX gene on Xp22.11-p22.2

Shirly Bar-David, Israela Lerer, Chava Kimchi Sarfaty, Zully Gelman Kohan, Vardiella Meiner, Joel Zlotogora, Dvorah Abeliovich

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

MRX genes of 2 families with X-linked mental retardation (XLMR) were localized by linkage analysis. In family A, the gene was mapped to Xp22.31- p22.32, with significant LOD scores to various Xp22 markers within a distance of 6 Mb between DXS1223 and DXS1224. The MRX gene of this family was designated MRX37. In a mentally retarded female who is a carrier of the MRX37 gene, a random pattern of X inactivation was demonstrated. In family B, a positive LOD score, although not significant (<+2), was found with the marker DXS1202 at Xp22.11-p22.2.

Original language	English
Pages (from-to)	83-88
Number of pages	6
Journal	American Journal of Medical Genetics
Volume	64
Issue number	1
DOIs	https://doi.org/10.1002/(SICI)1096-8628(19960712)64:1<83::AID-AJMG15>3.0.CO;2-O
State	Published - 12 Jul 1996
Externally published	Yes

Keywords

Fra(X)B
MRX genes
MRX37
X inactivation
Xp22

ASJC Scopus subject areas

Genetics(clinical)

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10.1002/(SICI)1096-8628(19960712)64:1<83::AID-AJMG15>3.0.CO;2-O

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Bar-David, S., Lerer, I., Sarfaty, C. K., Kohan, Z. G., Meiner, V., Zlotogora, J., & Abeliovich, D. (1996). Localization of two X-linked mental retardation (XLMR) genes to Xp: MRX37 gene at Xp22.31-p22.32 and a putative MRX gene on Xp22.11-p22.2. American Journal of Medical Genetics, 64(1), 83-88. https://doi.org/10.1002/(SICI)1096-8628(19960712)64:1<83::AID-AJMG15>3.0.CO;2-O

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title = "Localization of two X-linked mental retardation (XLMR) genes to Xp: MRX37 gene at Xp22.31-p22.32 and a putative MRX gene on Xp22.11-p22.2",

abstract = "MRX genes of 2 families with X-linked mental retardation (XLMR) were localized by linkage analysis. In family A, the gene was mapped to Xp22.31- p22.32, with significant LOD scores to various Xp22 markers within a distance of 6 Mb between DXS1223 and DXS1224. The MRX gene of this family was designated MRX37. In a mentally retarded female who is a carrier of the MRX37 gene, a random pattern of X inactivation was demonstrated. In family B, a positive LOD score, although not significant (<+2), was found with the marker DXS1202 at Xp22.11-p22.2.",

keywords = "Fra(X)B, MRX genes, MRX37, X inactivation, Xp22",

author = "Shirly Bar-David and Israela Lerer and Sarfaty, {Chava Kimchi} and Kohan, {Zully Gelman} and Vardiella Meiner and Joel Zlotogora and Dvorah Abeliovich",

year = "1996",

month = jul,

day = "12",

doi = "10.1002/(SICI)1096-8628(19960712)64:1<83::AID-AJMG15>3.0.CO;2-O",

language = "English",

volume = "64",

pages = "83--88",

journal = "American Journal of Medical Genetics",

issn = "0148-7299",

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Bar-David, S, Lerer, I, Sarfaty, CK, Kohan, ZG, Meiner, V, Zlotogora, J & Abeliovich, D 1996, 'Localization of two X-linked mental retardation (XLMR) genes to Xp: MRX37 gene at Xp22.31-p22.32 and a putative MRX gene on Xp22.11-p22.2', American Journal of Medical Genetics, vol. 64, no. 1, pp. 83-88. https://doi.org/10.1002/(SICI)1096-8628(19960712)64:1<83::AID-AJMG15>3.0.CO;2-O

TY - JOUR

T1 - Localization of two X-linked mental retardation (XLMR) genes to Xp

T2 - MRX37 gene at Xp22.31-p22.32 and a putative MRX gene on Xp22.11-p22.2

AU - Bar-David, Shirly

AU - Lerer, Israela

AU - Sarfaty, Chava Kimchi

AU - Kohan, Zully Gelman

AU - Meiner, Vardiella

AU - Zlotogora, Joel

AU - Abeliovich, Dvorah

PY - 1996/7/12

Y1 - 1996/7/12

N2 - MRX genes of 2 families with X-linked mental retardation (XLMR) were localized by linkage analysis. In family A, the gene was mapped to Xp22.31- p22.32, with significant LOD scores to various Xp22 markers within a distance of 6 Mb between DXS1223 and DXS1224. The MRX gene of this family was designated MRX37. In a mentally retarded female who is a carrier of the MRX37 gene, a random pattern of X inactivation was demonstrated. In family B, a positive LOD score, although not significant (<+2), was found with the marker DXS1202 at Xp22.11-p22.2.

AB - MRX genes of 2 families with X-linked mental retardation (XLMR) were localized by linkage analysis. In family A, the gene was mapped to Xp22.31- p22.32, with significant LOD scores to various Xp22 markers within a distance of 6 Mb between DXS1223 and DXS1224. The MRX gene of this family was designated MRX37. In a mentally retarded female who is a carrier of the MRX37 gene, a random pattern of X inactivation was demonstrated. In family B, a positive LOD score, although not significant (<+2), was found with the marker DXS1202 at Xp22.11-p22.2.

KW - Fra(X)B

KW - MRX genes

KW - MRX37

KW - X inactivation

KW - Xp22

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Localization of two X-linked mental retardation (XLMR) genes to Xp: MRX37 gene at Xp22.31-p22.32 and a putative MRX gene on Xp22.11-p22.2

Abstract

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