MRX genes of 2 families with X-linked mental retardation (XLMR) were localized by linkage analysis. In family A, the gene was mapped to Xp22.31- p22.32, with significant LOD scores to various Xp22 markers within a distance of 6 Mb between DXS1223 and DXS1224. The MRX gene of this family was designated MRX37. In a mentally retarded female who is a carrier of the MRX37 gene, a random pattern of X inactivation was demonstrated. In family B, a positive LOD score, although not significant (<+2), was found with the marker DXS1202 at Xp22.11-p22.2.
|Number of pages||6|
|Journal||American Journal of Medical Genetics|
|State||Published - 12 Jul 1996|
- MRX genes
- X inactivation