Abstract
We provide an experimental demonstration that the focusing of ionic currents in a micron size hole connecting two chambers can produce local temperature increases of up to 100°C with gradients as large as 1 °Kμ m-1. We find a good agreement between the measured temperature profiles and a finite elements-based numerical calculation. We show how the thermal gradients can be used to measure the full melting profile of DNA duplexes within a region of 40μm. The possibility to produce even larger gradients using submicron pores is discussed.
Original language | English |
---|---|
Article number | 163701 |
Journal | Applied Physics Letters |
Volume | 96 |
Issue number | 16 |
DOIs | |
State | Published - 19 Apr 2010 |
ASJC Scopus subject areas
- Physics and Astronomy (miscellaneous)