Long-lasting maintenance of learning-induced enhanced neuronal excitability: Mechanisms and functional significance

Drorit Saar, Edi Barkai

Research output: Contribution to journalReview articlepeer-review

32 Scopus citations

Abstract

Pyramidal neurons in the piriform cortex of olfactory discrimination trained rats show enhanced intrinsic neuronal excitability that lasts for several days after learning. Such enhanced intrinsic excitability is mediated by long-term reduction in the postburst after hyperpolarization which is generated by repetitive spike firing. The molecular machinery underlying such long-lasting modulation of intrinsic excitability, as well as its exceptional durability, is yet to be fully described. In this review, we present recent advancements that reveal the identity of the current that is modulated after learning and the second messenger system by which enhanced excitability is maintained. We also discuss the significance of such long-lasting modulation to the local network's sensitivity to noradrenaline, a major learning-relevant neuromodulator.

Original languageEnglish
Pages (from-to)171-177
Number of pages7
JournalMolecular Neurobiology
Volume39
Issue number3
DOIs
StatePublished - 1 Jan 2009
Externally publishedYes

Keywords

  • Noradrenaline
  • Olfactory learning
  • Pirifom cortex
  • Postburst AHP
  • Pyramidal neurons
  • Second messenger systems

ASJC Scopus subject areas

  • Neurology
  • Cellular and Molecular Neuroscience

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