Long Term Behavior of Lithographically Prepared In Vitro Neuronal Networks

Ronen Segev, Morris Benveniste, Eyal Hulata, Netta Cohen, Alexander Palevski, Yoash Shapira, Eli Kapon, Eshel Ben-Jacob

Research output: Contribution to journalArticlepeer-review

184 Scopus citations


We measured the long term spontaneous electrical activity of neuronal networks with different sizes, grown on lithographically prepared substrates and recorded with multi-electrode-array technology. The time sequences of synchronized bursting events were used to characterize network dynamics. All networks exhibit scale-invariant Lévy distributions and long-range correlations. These observations suggest that different-size networks self-organize to adjust their activities over many time scales. As predictions of current models differ from our observations, this calls for revised models.

Original languageEnglish GB
Article number118102
Pages (from-to)1181021-1181024
Number of pages4
JournalPhysical Review Letters
Issue number11
StatePublished - 18 Mar 2002
Externally publishedYes

ASJC Scopus subject areas

  • General Physics and Astronomy


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