Long-term effects of topiramate on bipolar mood instability, weight change and glycemic control: A case-series

K. N. Roy Chengappa, J. Levine, D. Rathore, H. Parepally, R. Atzert

Research output: Contribution to journalArticlepeer-review

86 Scopus citations

Abstract

Topiramate is an antiepileptic agent, which is being investigated as a mood-stabilizer. Three obese individuals with DSM-IV bipolar I disorder and type II diabetes mellitus received topiramate treatment in combination with antipsychotics and valproate or carbamazepine. In addition to improved mood stability, these individuals lost between 16 to 20.5% of their pre-topiramate body weight and also achieved significant glycemic control.

Original languageEnglish
Pages (from-to)186-190
Number of pages5
JournalEuropean Psychiatry
Volume16
Issue number3
DOIs
StatePublished - 1 Jan 2001
Externally publishedYes

Keywords

  • Bipolar disorder
  • Body mass index
  • Diabetes mellitus
  • Topiramate
  • Weight loss

ASJC Scopus subject areas

  • Psychiatry and Mental health

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