Abstract
Objective
To determine the risk of long-term hematological morbidity among children born following in-vitro fertilization (IVF) and ovulation induction (OI) as compared to spontaneous pregnancies.
Study Design
A population-based cohort study including all singleton deliveries occurring between the years 1991-2013 at a single tertiary medical center was performed. Fetuses with congenital malformations were excluded. Children delivered following pregnancies achieved by IVF, OI and spontaneous pregnancies were compared. Hospitalizations up to the age of 18 years involving hematological morbidity were evaluated. The following hematological morbidities were compared: immune deficiency, hereditary anemia, acquired anemia, pancytopenia, coagulation disorders, and leukocytes disorders. A Kaplan-Meier survival curve was used to compare cumulative morbidity incidence. A Cox regression model was used to control for confounders.
Results
During the study period 242 187 singleton deliveries met the inclusion criteria; 0.5% were following IVF (n=1160), and 1.2% occurred following OI (n=2853). Hospitalization rates up to the age of 18 years involving hematological morbidity did not differ between children delivered following IVF (1.1%), OI (0.7%) and spontaneous pregnancies (0.7%; p=0.15). The Kaplan-Meier survival curve demonstrated comparable cumulative incidence of hematological morbidity following IVF and OI (Figure, log rank p=0.14). Selected hematological morbidities are presented in the table. Using the cox regression model while controlling for multiple confounders such as maternal age, preterm delivery (<37 weeks), birth weight, maternal diabetes, and hypertensive disorders in pregnancy, no association was noted between IVF (adjusted HR=1.46, CI 0.8-2.5, p=0.172), or OI (adjusted HR= 1.29, CI 0.8-1.9, p=0.23), and long-term pediatric hematological morbidity.
Conclusion
Singletons conceived following ART do not appear to be at an increased risk for long-term hematological morbidity as compared to spontaneously conceived singletons.
To determine the risk of long-term hematological morbidity among children born following in-vitro fertilization (IVF) and ovulation induction (OI) as compared to spontaneous pregnancies.
Study Design
A population-based cohort study including all singleton deliveries occurring between the years 1991-2013 at a single tertiary medical center was performed. Fetuses with congenital malformations were excluded. Children delivered following pregnancies achieved by IVF, OI and spontaneous pregnancies were compared. Hospitalizations up to the age of 18 years involving hematological morbidity were evaluated. The following hematological morbidities were compared: immune deficiency, hereditary anemia, acquired anemia, pancytopenia, coagulation disorders, and leukocytes disorders. A Kaplan-Meier survival curve was used to compare cumulative morbidity incidence. A Cox regression model was used to control for confounders.
Results
During the study period 242 187 singleton deliveries met the inclusion criteria; 0.5% were following IVF (n=1160), and 1.2% occurred following OI (n=2853). Hospitalization rates up to the age of 18 years involving hematological morbidity did not differ between children delivered following IVF (1.1%), OI (0.7%) and spontaneous pregnancies (0.7%; p=0.15). The Kaplan-Meier survival curve demonstrated comparable cumulative incidence of hematological morbidity following IVF and OI (Figure, log rank p=0.14). Selected hematological morbidities are presented in the table. Using the cox regression model while controlling for multiple confounders such as maternal age, preterm delivery (<37 weeks), birth weight, maternal diabetes, and hypertensive disorders in pregnancy, no association was noted between IVF (adjusted HR=1.46, CI 0.8-2.5, p=0.172), or OI (adjusted HR= 1.29, CI 0.8-1.9, p=0.23), and long-term pediatric hematological morbidity.
Conclusion
Singletons conceived following ART do not appear to be at an increased risk for long-term hematological morbidity as compared to spontaneously conceived singletons.
| Original language | English GB |
|---|---|
| Pages (from-to) | S350-S350 |
| Journal | American Journal of Obstetrics and Gynecology |
| Volume | 216 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 2017 |