Long-term neurological morbidity of offspring born to women with systemic lupus erythematosus

Dora Davidov, Gali Pariente, Tamar Wainstock, Eyal Sheiner

Research output: Contribution to journalMeeting Abstract


Pregnancies in the setting of systemic lupus erythematosus (SLE) are associated with adverse outcomes, among them is preterm delivery. As preterm delivery is associated with long-term neurological morbidity of the offspring, we opted to evaluate the long-term neurologic outcomes of offspring born to mothers with SLE.
Study Design
In a population-based retrospective cohort study, the incidence of long-term neurological morbidity was compared between offspring to women with and without SLE. Deliveries occurred between the years 1991 and 2014 in a tertiary medical centre. Neurological morbidities were assessed up to age of 18 years according to predefined set of ICD-9 codes associated with hospitalization of the offspring. Multifetal pregnancies, cases of congenital anomalies, and perinatal mortality were excluded from the study. A Kaplan-Meier survival curve was used to compare cumulative neurological morbidity incidence.

During the study period, 243682 deliveries were included, of which 96 (0.04%) were of women with SLE. Children born to women with SLE did not exhibit a higher rate of long-term neurologic morbidity compared with children of women without SLE (4.2% vs 3.1%, P=0.546). Likewise, the Kaplan-Meier survival curve did not demonstrate a significantly higher cumulative incidence of long-term neurological morbidity in offspring of women with SLE (log rank p=0.429, Figure).
Despite the association of preterm deliveries with maternal SLE, no significant difference in long-term neurological mor
Original languageEnglish
Pages (from-to)S297-S297
JournalAmerican Journal of Obstetrics and Gynecology
Issue number1, Supplement
StatePublished - Jan 2020


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