TY - JOUR
T1 - Longevity network
T2 - Construction and implications
AU - Budovsky, Arie
AU - Abramovich, Amir
AU - Cohen, Raphael
AU - Chalifa-Caspi, Vered
AU - Fraifeld, Vadim
N1 - Funding Information:
This study was supported by grant from the Center for Multidisciplinary Research in Aging, Ben-Gurion University of the Negev (to V.F.). We thank Dr. Irving Listowsky and Dr. Aviv Bergman (both from the Albert Einstein College of Medicine, Bronx, NY) for critical reading of the manuscript. We also appreciate the assistance of Mrs. Reut Mali (Ben-Gurion University of the Negev) in preparation of the manuscript. The comments of anonymous referees were extremely helpful for improving the paper. We were pleased to find out that 10 out of 10 newly reported longevity-associated genes with annotated PPIs in BioGRID were already present in the constructed longevity networks (CLN and ELN).
PY - 2007/1/1
Y1 - 2007/1/1
N2 - The vast majority of studies on longevity have focused on individual genes/proteins, without adequately addressing the possible role of interactions between them. This study is the first attempt towards constructing a "longevity network" via analysis of human protein-protein interactions (PPIs). For this purpose, we (i) compiled a complete list of established longevity genes from different species, including those that most probably affect the longevity in humans, (ii) defined the human orthologs of the longevity genes, and (iii) determined whether the encoded proteins could be organized as a network. The longevity gene-encoded proteins together with their interacting proteins form a continuous network, which fits the criteria for a scale-free network with an extremely high contribution of hubs to the network connectivity. Most of them have never been annotated before in connection with longevity. Remarkably, almost all of the hubs of the "longevity network" were reported to be involved in at least one age-related disease (ARD), with many being involved in several ARDs. This may be one of the ways by which the proteins with multiple interactions affect the longevity. The hubs offer the potential of being primary targets for longevity-promoting interventions.
AB - The vast majority of studies on longevity have focused on individual genes/proteins, without adequately addressing the possible role of interactions between them. This study is the first attempt towards constructing a "longevity network" via analysis of human protein-protein interactions (PPIs). For this purpose, we (i) compiled a complete list of established longevity genes from different species, including those that most probably affect the longevity in humans, (ii) defined the human orthologs of the longevity genes, and (iii) determined whether the encoded proteins could be organized as a network. The longevity gene-encoded proteins together with their interacting proteins form a continuous network, which fits the criteria for a scale-free network with an extremely high contribution of hubs to the network connectivity. Most of them have never been annotated before in connection with longevity. Remarkably, almost all of the hubs of the "longevity network" were reported to be involved in at least one age-related disease (ARD), with many being involved in several ARDs. This may be one of the ways by which the proteins with multiple interactions affect the longevity. The hubs offer the potential of being primary targets for longevity-promoting interventions.
KW - Age-related diseases
KW - Longevity genes and proteins
KW - Longevity network
KW - Protein-protein interactions
UR - http://www.scopus.com/inward/record.url?scp=33846115831&partnerID=8YFLogxK
U2 - 10.1016/j.mad.2006.11.018
DO - 10.1016/j.mad.2006.11.018
M3 - Article
AN - SCOPUS:33846115831
SN - 0047-6374
VL - 128
SP - 117
EP - 124
JO - Mechanisms of Ageing and Development
JF - Mechanisms of Ageing and Development
IS - 1
ER -
