Losses of 25-hydroxyvitamin D in peritoneal fluid: Possible mechanism for bone disease in uremic patients treated with chronic ambulatory peritoneal dialysis

Y. Aloni, S. Shany, C. Chaimovitz

Research output: Contribution to journalArticlepeer-review

36 Scopus citations

Abstract

Despite a good control of serum phosphate levels, bone disease still occurs in patients treated with chronic ambulatory peritoneal dialysis (CAPD). The purpose of this study was to determine if 25-hydroxyvitamin D (25-OH-D) penetrates through the peritoneal membrane and whether chronic peritoneal dialysis may thereby decrease the serum 25-OH-D levels. In 10 CAPD-treated patients the serum 25-OH-D was 8.8 ± 1.1 ng/ml, which is significantly lower than in the hemodialysis-treated group (15.5 ± 2.3 ng/ml) and lower than in healthy controls (30.3 ± 3.6 ng/ml). The mean total daily loss of 25-OH-D in the peritoneal fluid was 1,491 ± 260 ng/day. The serum 25-OH-D binding capacity was significantly lower in the CAPD group than in normal controls. The mean daily loss of 25-OH-D binding capacity in the dialysate was 153 ± 28 nmol/day. We conclude that permeability of the peritoneal membrane to middle-size proteins leads to loss of 25-OH-D binding protein, and this increases loss of 25-OH-D. Low levels of 25-OH-D in plasma may aggravate the symptoms of osteodystrophy of renal failure in patients treated with CAPD.

Original languageEnglish
Pages (from-to)82-86
Number of pages5
JournalMineral and Electrolyte Metabolism
Volume9
Issue number2
StatePublished - 1 Jan 1983
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry

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