Low levels of vitamin-D are associated with neuropathy and lymphoma among patients with Sjögren's syndrome

Nancy Agmon-Levin, Shaye Kivity, Athanasios G. Tzioufas, Marcus López Hoyos, Blaz Rozman, Inga Efes, Yinon Shapira, Ari Shamis, Howard Amital, Pierre Youinou, Yehuda Shoenfeld

Research output: Contribution to journalArticlepeer-review

68 Scopus citations


Background/purpose: Primary Sjögren's syndrome (SS) is a chronic autoimmune disease primarily involving the exocrine glands. The clinical picture of SS ranges from exocrinopathy to systemic disease affecting the lung, kidney, liver, skin, musculockeletal and nervous systems. The morbidity of SS is mainly determined by extraglandular disease and increased prevalence of lymphoma. Environmental and hormonal factors, such as vitamin-D may play a role in the pathogenic process and disease expression. Thus, we aimed to evaluate levels of vitamin-D and their association with manifestations of SS. Methods: Vitamin-D levels were determined in 176 primary SS patients and 163 matched healthy volunteers utilizing the LIAISON chemiluminescent immunoassays (DiaSorin-Italy). A correlation between vitamin-D levels and clinical and serological manifestations of SS was performed. Results: Mean vitamin-D levels were comparable between SS patients and control 21.2 ± 9.4 ng/ml and 22.4 ± 10 ng/ml, respectively. Peripheral neuropathy was diagnosed in 23% of SS patients and associated with lower vitamin-D levels (18.6 ± 5.5 ng/ml vs. 22.6±8 ng/ml (p = 0.04)). Lymphoma was diagnosed in 4.3% of SS patients, who had lower levels of vitamin-D (13.2 ± 6.25 ng/ml), compared to SS patients without lymphoma (22 ± 8 ng/ml), (p = 0.03). Other clinical and serological manifestations did not correlate with vitamin-D status. Conclusions: In this study, low levels of vitamin-D correlated with the presence of peripheral neuropathy and lymphoma among SS patients. The link between vitamin-D and neuropathy or lymphoma was reported in other conditions, and may support a role for vitamin-D in the pathogenesis of these processes. Plausible beneficial effect for vitamin-D supplementation may thus be suggested.

Original languageEnglish
Pages (from-to)234-239
Number of pages6
JournalJournal of Autoimmunity
Issue number3
StatePublished - 1 Sep 2012
Externally publishedYes


  • Autoimmunity
  • Lymphoma
  • Neuropathy
  • Sjögren's syndrome
  • Vitamin-D

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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